FAIM (Fas Apoptotic Inhibitory Molecule)
A key regulator of apoptosis and cell survival
Gene Information Card
| Symbol | FAIM |
|---|---|
| Full Name | Fas Apoptotic Inhibitory Molecule |
| Gene Type | protein-coding |
| Chromosomal Location | 3q22.3 |
| NCBI Gene ID | 55179 ncbi.nlm.nih.gov/gene/55179 |
| Ensembl ID | ENSG00000114520 |
| UniProt ID | Q9NYB0 |
| OMIM ID | 606084 |
| HGNC ID | 17067 |
| Aliases | FAIM1, FAIM-L, FAIM-S |
Description
FAIM (Fas Apoptotic Inhibitory Molecule) is a protein-coding gene that encodes an anti-apoptotic protein. It protects cells from Fas-induced apoptosis and is involved in neuronal survival, immune regulation, and cancer cell resistance to cell death. Alternative splicing produces two isoforms: FAIM-L (long) and FAIM-S (short).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Alzheimer disease | FAIM downregulation increases neuronal vulnerability to apoptosis | PMID: 19013282 |
| Hepatocellular carcinoma | FAIM overexpression promotes tumor cell survival | PMID: 23541953 |
| Colorectal cancer | FAIM upregulation confers resistance to Fas-mediated apoptosis | PMID: 21804531 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Liver | 8.7 | Low |
| Lung | 6.2 | Low |
| Spleen | 15.1 | Medium |
| Testis | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.5 | Embryonic kidney |
| HeLa | 7.8 | Cervical cancer |
| HepG2 | 14.2 | Hepatocellular carcinoma |
| SH-SY5Y | 11.0 | Neuroblastoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.214C>T | missense | <0.01% | p.Arg72Trp; unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Fas signaling pathway (KEGG: hsa04650)
• Apoptosis (KEGG: hsa04210)
Protein Summary
FAIM is a small anti-apoptotic protein (approx. 20 kDa) that inhibits Fas-mediated cell death by interfering with caspase-8 activation. It is widely expressed in tissues, with highest levels in brain and spleen. Two isoforms exist: FAIM-L (long) contains an additional exon and is more potent in neuroprotection; FAIM-S (short) is ubiquitously expressed. FAIM also modulates NF-κB signaling and is implicated in cancer cell survival and neurodegenerative diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAIM2 Knockout HEK293 Cell Line | EDJ-KQ7776 | Human | 23017 | Details Get a Quote |
| FAIM Knockout HEK293 Cell Line | EDJ-KQ13353 | Human | 55179 | Details Get a Quote |
| FAIM Knockout HCT 116 Cell Line | EDJ-KQ41605 | Human | 55179 | Details Get a Quote |
| FAIM Knockout A-549 Cell Line | EDJ-KQ42835 | Human | 55179 | Details Get a Quote |
| FAIM Knockout HeLa Cell Line | EDJ-KQ42836 | Human | 55179 | Details Get a Quote |
| FAIM2 Knockout HeLa Cell Line | EDJ-KQ55674 | Human | 23017 | Details Get a Quote |
| FAIM2 Knockout A-549 Cell Line | EDJ-KQ64172 | Human | 23017 | Details Get a Quote |
| FAIM2 Knockout HCT 116 Cell Line | EDJ-KQ72615 | Human | 23017 | Details Get a Quote |
