FABP7 (Fatty Acid Binding Protein 7, Brain)
A brain-type fatty acid binding protein involved in lipid transport, neurodevelopment, and cancer progression.
Gene Information Card
| Symbol | FABP7 |
|---|---|
| Full Name | Fatty Acid Binding Protein 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q22.31 |
| NCBI Gene ID | 2173 ncbi.nlm.nih.gov/gene/2173 |
| Ensembl ID | ENSG00000164434 |
| UniProt ID | P55029 |
| OMIM ID | 602965 |
| HGNC ID | 3560 |
| Aliases | BLBP, B-FABP, FABPB, MRG |
Description
FABP7 encodes the brain-type fatty acid binding protein (B-FABP), a small cytoplasmic protein that binds long-chain fatty acids and retinoic acid. It is primarily expressed in radial glial cells and astrocytes during central nervous system development, where it regulates lipid homeostasis, cell proliferation, and differentiation. In adults, FABP7 is re-expressed in certain cancers, including glioblastoma and breast cancer, and is associated with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | Overexpression of FABP7 promotes tumor cell migration and invasion via PPARγ signaling | PMID: 19029981; COSMIC overexpression data |
| Breast cancer | FABP7 expression correlates with basal-like subtype and reduced survival | PMID: 21746838; ClinVar germline variants |
| Astrocytoma | FABP7 upregulation linked to malignant progression | PMID: 15607977; NCBI Gene RIF |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Adipose tissue | 0.8 | Low |
| Breast | 0.3 | Low |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| U-87 MG (glioblastoma) | 15.2 | High expression |
| MCF7 (breast cancer) | 0.5 | Low expression |
| HEK293 (embryonic kidney) | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.199G>A (p.Ala67Thr) | Missense | <0.01% (gnomAD) | Unknown functional effect; ClinVar VUS |
| c.332C>T (p.Pro111Leu) | Missense | <0.01% (gnomAD) | Unknown functional effect; ClinVar VUS |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Overexpression in glioblastoma suggests potential gain-of-function in tumorigenesis.
Dominant Negative (DN)
No dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
| • fatty acid binding (GO:0005504) | • lipid binding (GO:0008289) |
| • fatty acid transport (GO:0015908) | • central nervous system development (GO:0007417) |
| • response to drug (GO:0042493) |
Pathways
• PPAR signaling pathway (KEGG: hsa03320)
• Fatty acid metabolism (Reactome: R-HSA-8978868)
Protein Summary
FABP7 (B-FABP) is a 132-amino acid protein (15 kDa) that belongs to the fatty acid binding protein family. It adopts a β-barrel structure that encapsulates hydrophobic ligands such as docosahexaenoic acid (DHA) and oleic acid. FABP7 shuttles fatty acids to nuclear receptors (e.g., PPARγ) to modulate gene expression. In the brain, it is essential for radial glial cell morphology and neurogenesis. In cancer, FABP7 enhances lipid metabolism and signaling pathways that drive invasion and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FABP7 Knockout HEK293 Cell Line | EDJ-KQ4573 | Human | 2173 | Details Get a Quote |
| FABP7 Knockout HeLa Cell Line | EDJ-KQ27226 | Human | 2173 | Details Get a Quote |
| FABP7 Knockout A-549 Cell Line | EDJ-KQ61678 | Human | 2173 | Details Get a Quote |
| FABP7 Knockout HCT 116 Cell Line | EDJ-KQ70161 | Human | 2173 | Details Get a Quote |
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