FABP12
Fatty Acid Binding Protein 12
Gene Information Card
| Symbol | FABP12 |
|---|---|
| Full Name | Fatty Acid Binding Protein 12 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q21.13 |
| NCBI Gene ID | 646480 ncbi.nlm.nih.gov/gene/646480 |
| Ensembl ID | ENSG00000197976 |
| UniProt ID | Q0P630 |
| OMIM ID | 617933 |
| HGNC ID | 32383 |
| Aliases | FABP-12, MGC138499 |
Description
FABP12 encodes a member of the fatty acid binding protein (FABP) family, which binds long-chain fatty acids and other hydrophobic ligands. It is thought to play a role in intracellular lipid transport and metabolism, particularly in the testis and certain cancer cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of FABP12 may promote lipid uptake and tumor growth | PMID: 25982908 |
| Testicular germ cell tumors | Altered FABP12 expression linked to lipid metabolism in tumor cells | PMID: 25982908 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 5.2 | Low |
| Adipose tissue | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 15.8 | High expression |
| LNCaP (prostate cancer) | 8.4 | Moderate expression |
| NTERA-2 (testicular germ cell) | 10.2 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.152C>T (p.Pro51Leu) | Missense | <0.01% | Unknown functional effect |
| c.289G>A (p.Val97Met) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • fatty acid binding (GO:0005504) | • cytoplasm (GO:0005737) |
| • fatty acid transport (GO:0015908) |
Pathways
• PPAR signaling pathway (Reactome: R-HSA-1989781)
• Fatty acid metabolism (KEGG: hsa00071)
Protein Summary
FABP12 is a 132-amino acid protein that belongs to the intracellular lipid-binding protein family. It adopts a beta-barrel structure that encapsulates hydrophobic ligands such as long-chain fatty acids. Its expression is enriched in testis and prostate, and it may facilitate lipid trafficking in steroidogenic tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FABP12 Knockout HEK293 Cell Line | EDJ-KQ13351 | Human | 646486 | Details Get a Quote |
| FABP12 Knockout HeLa Cell Line | EDJ-KQ60606 | Human | 646486 | Details Get a Quote |
| FABP12 Knockout A-549 Cell Line | EDJ-KQ69076 | Human | 646486 | Details Get a Quote |
| FABP12 Knockout HCT 116 Cell Line | EDJ-KQ77429 | Human | 646486 | Details Get a Quote |
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