EPHA10: Ephrin Receptor A10 - A Comprehensive Gene Resource
EPHA10 gene, protein, expression, mutations, and associated diseases
Gene Information Card
| Symbol | EPHA10 |
|---|---|
| Full Name | EPH receptor A10 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p34.2 |
| NCBI Gene ID | 284656 ncbi.nlm.nih.gov/gene/284656 |
| Ensembl ID | ENSG00000183317 |
| UniProt ID | Q5JZY3 |
| OMIM ID | 611123 |
| HGNC ID | 19906 |
| Aliases | FLJ33996, MGC138227, MGC138229 |
Description
EPHA10 (EPH receptor A10) is a member of the ephrin receptor subfamily of receptor tyrosine kinases. It is involved in cell-cell signaling, development, and cancer progression. The gene is located on chromosome 1p34.2 and encodes a protein that binds ephrin-A ligands.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of EPHA10 promotes tumor growth and metastasis via activation of downstream signaling pathways. | PMID: 21573172 |
| Prostate cancer | EPHA10 is upregulated in prostate cancer and associated with poor prognosis. | PMID: 23454750 |
| Colorectal cancer | EPHA10 expression correlates with tumor stage and lymph node metastasis. | PMID: 25636587 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.3 | Low |
| Breast | 1.2 | Medium |
| Prostate | 0.8 | Low |
| Colon | 0.5 | Low |
| Testis | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 1.5 | Moderate expression |
| PC3 (prostate cancer) | 0.9 | Low expression |
| HT29 (colorectal cancer) | 0.6 | Low expression |
| HEK293 (embryonic kidney) | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.1% | Unknown functional effect |
| c.567C>T (p.Arg189Trp) | Missense | <0.1% | Unknown functional effect |
| c.2345_2346insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.2345_2346insA) are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been reported.
View complete mutation data：
Gene Ontology (GO)
| • transmembrane receptor protein tyrosine kinase activity (GO:0004714) | • transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) |
| • integral component of membrane (GO:0016021) | • plasma membrane (GO:0005886) |
| • ephrin receptor activity (GO:0048011) |
Pathways
• Ephrin receptor signaling pathway (Reactome: R-HSA-3928665)
• Ephrin-A forward signaling (Reactome: R-HSA-3928662)
Protein Summary
EPHA10 is a receptor tyrosine kinase that binds ephrin-A ligands. It is involved in cell adhesion, migration, and angiogenesis. The protein is expressed in various tissues and is implicated in cancer progression, particularly in breast, prostate, and colorectal cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EPHA10 Knockout HEK293 Cell Line | EDJ-KQ13303 | Human | 284656 | Details Get a Quote |
| EPHA10 Knockout HCT 116 Cell Line | EDJ-KQ41522 | Human | 284656 | Details Get a Quote |
| EPHA10 Knockout HeLa Cell Line | EDJ-KQ59485 | Human | 284656 | Details Get a Quote |
| EPHA10 Knockout A-549 Cell Line | EDJ-KQ67952 | Human | 284656 | Details Get a Quote |
