ENY2
ENY2 Transcription and Export Complex 2 Subunit
Gene Information Card
| Symbol | ENY2 |
|---|---|
| Full Name | ENY2 Transcription and Export Complex 2 Subunit |
| Gene Type | Protein-coding |
| Chromosomal Location | 8q23.1 |
| NCBI Gene ID | 56943 ncbi.nlm.nih.gov/gene/56943 |
| Ensembl ID | ENSG00000104738 |
| UniProt ID | Q9NPA3 |
| OMIM ID | 609447 |
| HGNC ID | 29114 |
| Aliases | ENY2, DC6, ENY-2, ENY2 transcription and export complex 2 subunit |
Description
ENY2 encodes a component of the transcription and export complex 2 (TREX-2) and the SAGA (Spt-Ada-Gcn5-acetyltransferase) complex. It plays a critical role in transcription elongation, mRNA export from the nucleus, and chromatin modification. ENY2 is involved in coupling transcription with mRNA processing and export, and its dysregulation has been implicated in cancer and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | ENY2 overexpression may enhance transcription of oncogenes and promote cell proliferation | COSMIC; PMID: 25691885 |
| Colorectal cancer | ENY2 amplification correlates with poor prognosis and increased tumor growth | COSMIC; PMID: 27323850 |
| Hepatocellular carcinoma | ENY2 upregulation linked to altered mRNA export and tumor progression | COSMIC; PMID: 28723891 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 9.8 | Medium |
| Brain | 6.2 | Low |
| Liver | 5.1 | Low |
| Kidney | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.7 | Embryonic kidney cells |
| HeLa | 7.4 | Cervical carcinoma cells |
| HepG2 | 6.1 | Hepatocellular carcinoma cells |
| MCF7 | 5.9 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional impact |
| c.214C>T | Nonsense | <0.1% | Predicted loss of function |
| c.347G>A | Missense | <0.1% | May affect protein stability |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.214C>T) likely result in truncated protein and loss of function.
Gain of Function (GOF)
Not well documented; overexpression in cancer suggests possible gain-of-function role.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • nucleus (GO:0005634) | • nucleoplasm (GO:0005654) |
| • cytosol (GO:0005829) | • regulation of transcription (GO:0006355) |
| • mRNA export from nucleus (GO:0006406) | • histone acetylation (GO:0016573) |
| • histone methyltransferase complex (GO:0035097) | • protein N-terminus binding (GO:0047485) |
Pathways
• mRNA export from nucleus (TREX-2 complex)
• Chromatin modification (SAGA complex)
• Transcription elongation
Protein Summary
ENY2 is a 101-amino acid protein that functions as a scaffold within the TREX-2 and SAGA complexes. It facilitates the coupling of transcription elongation with mRNA export by bridging the transcription machinery with nuclear pore components. ENY2 also participates in histone acetylation and deubiquitination, influencing chromatin dynamics and gene expression. Its overexpression in various cancers suggests a role in oncogenic transcriptional programs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ENY2 Knockout HEK293 Cell Line | EDJ-KQ51543 | Human | 56943 | Details Get a Quote |
| ENY2 Knockout HeLa Cell Line | EDJ-KQ56773 | Human | 56943 | Details Get a Quote |
| ENY2 Knockout A-549 Cell Line | EDJ-KQ65276 | Human | 56943 | Details Get a Quote |
| ENY2 Knockout HCT 116 Cell Line | EDJ-KQ73719 | Human | 56943 | Details Get a Quote |
