ENOX2
Ecto-NOX Disulfide-Thiol Exchanger 2
Gene Information Card
| Symbol | ENOX2 |
|---|---|
| Full Name | Ecto-NOX Disulfide-Thiol Exchanger 2 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 10495 ncbi.nlm.nih.gov/gene/10495 |
| Ensembl ID | ENSG00000101974 |
| UniProt ID | Q16206 |
| OMIM ID | 300226 |
| HGNC ID | 3350 |
| Aliases | tNOX, CNOX, COVA1, MGC138290 |
Description
ENOX2 encodes a cell surface NADH oxidase that functions as a disulfide-thiol exchanger. It is constitutively expressed in cancer cells and is involved in cell growth, proliferation, and resistance to apoptosis. The protein is also known as tumor-associated NADH oxidase (tNOX) and is a target for anticancer therapies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression of ENOX2 in tumor cells promotes cell growth and resistance to apoptosis; used as a biomarker for cancer detection. | PMID: 15542782, PMID: 19167516 |
| Alzheimer's disease | Altered ENOX2 activity may contribute to oxidative stress and neurodegeneration. | PMID: 15331597 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 0.2 | Low |
| Breast | 0.1 | Low |
| Liver | 0.1 | Low |
| Lung | 0.1 | Low |
| Colon | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.5 | Cervical cancer cell line |
| MCF7 | 0.3 | Breast cancer cell line |
| A549 | 0.4 | Lung cancer cell line |
| HepG2 | 0.3 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown effect |
| c.100C>T | missense | <0.1% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in cancer suggests gain-of-function activity.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • NAD(P)H oxidase activity | • protein disulfide oxidoreductase activity |
| • cell surface | • plasma membrane |
| • oxidation-reduction process |
Pathways
• NADH oxidation
• disulfide-thiol exchange
Protein Summary
ENOX2 is a 70 kDa cell surface glycoprotein with NADH oxidase activity. It catalyzes the oxidation of NADH and the reduction of protein disulfide bonds, regulating cell growth and redox balance. The protein is overexpressed in many cancers and is a target for the anticancer drug capsaicin.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ENOX2 Knockout HEK293 Cell Line | EDJ-KQ7067 | Human | 10495 | Details Get a Quote |
| ENOX2 Knockout A-549 Cell Line | EDJ-KQ31887 | Human | 10495 | Details Get a Quote |
| ENOX2 Knockout HCT 116 Cell Line | EDJ-KQ31888 | Human | 10495 | Details Get a Quote |
| ENOX2 Knockout HeLa Cell Line | EDJ-KQ31889 | Human | 10495 | Details Get a Quote |
