ELOA2
Elongin A2, a transcription elongation factor subunit
Gene Information Card
| Symbol | ELOA2 |
|---|---|
| Full Name | elongin A2 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 10014 ncbi.nlm.nih.gov/gene/10014 |
| Ensembl ID | ENSG00000140937 |
| UniProt ID | Q8IY92 |
| OMIM ID | 609013 |
| HGNC ID | 24259 |
| Aliases | TCEB3C, elongin A2, SIII p110 |
Description
ELOA2 (elongin A2) encodes a subunit of the elongin complex, which stimulates RNA polymerase II transcription elongation by suppressing transient pausing. The protein interacts with elongin BC complex to form the fully active elongin (SIII) complex. ELOA2 is expressed in various tissues and may play roles in cellular proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 6.8 | Low |
| Lung | 5.2 | Low |
| Liver | 4.1 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.3 | Moderate expression |
| HeLa | 6.1 | Low expression |
| K562 | 4.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • transcription elongation factor activity | • RNA polymerase II transcription elongation |
| • nucleus | • protein binding |
Pathways
• RNA polymerase II transcription elongation
• Elongin complex pathway
Protein Summary
ELOA2 is a 110 kDa protein that forms the elongin (SIII) complex with elongin B and C. It enhances RNA polymerase II processivity by reducing pausing. The protein contains a von Hippel-Lindau binding domain and is involved in transcriptional regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ELOA2 Knockout HEK293 Cell Line | EDJ-KQ10980 | Human | 51224 | Details Get a Quote |
| ELOA2 Knockout HeLa Cell Line | EDJ-KQ56254 | Human | 51224 | Details Get a Quote |
| ELOA2 Knockout A-549 Cell Line | EDJ-KQ64743 | Human | 51224 | Details Get a Quote |
| ELOA2 Knockout HCT 116 Cell Line | EDJ-KQ73188 | Human | 51224 | Details Get a Quote |
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