EIF4G2
Eukaryotic Translation Initiation Factor 4 Gamma 2
Gene Information Card
| Symbol | EIF4G2 |
|---|---|
| Full Name | eukaryotic translation initiation factor 4 gamma 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 1982 ncbi.nlm.nih.gov/gene/1982 |
| Ensembl ID | ENSG00000110321 |
| UniProt ID | P78344 |
| OMIM ID | 602325 |
| HGNC ID | 3296 |
| Aliases | p97, DAP5, NAT1 |
Description
EIF4G2 (eukaryotic translation initiation factor 4 gamma 2) encodes a component of the eukaryotic translation initiation factor 4F (eIF4F) complex. Unlike the canonical eIF4G1, EIF4G2 lacks the poly(A)-binding protein (PABP) binding site and is involved in cap-independent translation initiation, particularly under stress conditions such as apoptosis and viral infection. It plays a role in cellular proliferation, differentiation, and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of EIF4G2 expression alters cap-independent translation of oncogenic mRNAs, promoting tumorigenesis. | COSMIC, PubMed |
| Neurodegenerative disorders | Altered EIF4G2 levels affect translation of proteins involved in neuronal survival and stress response. | PubMed |
| Viral infections | EIF4G2 is cleaved by viral proteases (e.g., poliovirus, HIV) to shut off host translation, facilitating viral replication. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.3 | Cervical cancer cell line |
| HEK293 | 11.8 | Embryonic kidney cell line |
| K562 | 9.5 | Leukemia cell line |
| MCF7 | 10.2 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.01% | Unknown |
| c.567_568del | frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity (GO:0003743) | • translational initiation (GO:0006413) |
| • cytoplasm (GO:0005737) | • membrane (GO:0016020) |
| • RNA binding (GO:0003723) |
Pathways
• hsa03013 - RNA transport
• hsa04141 - Protein processing in endoplasmic reticulum
• hsa05160 - Hepatitis C
• hsa05161 - Hepatitis B
Protein Summary
EIF4G2 (p97/DAP5) is a 907-amino acid protein that functions as a scaffold in the eIF4F complex. It binds eIF4E and eIF3 but lacks the PABP-interacting domain, enabling cap-independent translation. It is cleaved by caspases during apoptosis and by viral proteases, modulating host translation. The protein is widely expressed and implicated in cancer, viral infection, and cellular stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF4G2 Knockout HEK293 Cell Line | EDJ-KQ2109 | Human | 1982 | Details Get a Quote |
| EIF4G2 Knockout HCT 116 Cell Line | EDJ-KQ22235 | Human | 1982 | Details Get a Quote |
| EIF4G2 Knockout HeLa Cell Line | EDJ-KQ22236 | Human | 1982 | Details Get a Quote |
| EIF4G2 Knockout A-549 Cell Line | EDJ-KQ61623 | Human | 1982 | Details Get a Quote |
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