EIF4EBP3
Eukaryotic Translation Initiation Factor 4E Binding Protein 3
Gene Information Card
| Symbol | EIF4EBP3 |
|---|---|
| Full Name | Eukaryotic Translation Initiation Factor 4E Binding Protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | 8637 ncbi.nlm.nih.gov/gene/8637 |
| Ensembl ID | ENSG00000113578 |
| UniProt ID | Q9BQ09 |
| OMIM ID | 605466 |
| HGNC ID | 3289 |
| Aliases | 4E-BP3, eIF4E-binding protein 3 |
Description
EIF4EBP3 encodes a member of the eukaryotic translation initiation factor 4E (eIF4E) binding protein family. The protein binds to eIF4E and inhibits cap-dependent translation initiation. Its activity is regulated by mTOR-mediated phosphorylation, which releases eIF4E to promote translation. EIF4EBP3 is implicated in cellular growth, proliferation, and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of eIF4E binding alters translation of oncogenic mRNAs | PMID: 12080057 |
| Breast cancer | Overexpression of EIF4EBP3 may modulate eIF4E availability | PMID: 15626733 |
| Prostate cancer | Altered expression linked to mTOR pathway activity | PMID: 18426908 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 5.2 | Low |
| Brain | 3.8 | Low |
| Breast | 4.1 | Low |
| Colon | 6.0 | Medium |
| Kidney | 5.5 | Medium |
| Liver | 4.9 | Low |
| Lung | 5.8 | Medium |
| Muscle | 3.5 | Low |
| Pancreas | 4.0 | Low |
| Prostate | 6.3 | Medium |
| Skin | 4.7 | Low |
| Spleen | 5.0 | Low |
| Testis | 7.2 | Medium |
| Thyroid | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 6.5 | Cervical cancer cell line |
| HEK 293 | 5.8 | Embryonic kidney cell line |
| MCF7 | 7.0 | Breast cancer cell line |
| PC3 | 6.2 | Prostate cancer cell line |
| A549 | 5.9 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown significance |
| c.100C>T | missense | <0.01% | Unknown significance |
| c.200G>A | synonymous | <0.01% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in EIF4EBP3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• mTOR signaling pathway (Reactome: R-HSA-165159)
• Translation initiation (Reactome: R-HSA-72649)
• Signaling by mTOR (Reactome: R-HSA-165159)
Protein Summary
EIF4EBP3 (4E-BP3) is a 100-amino acid protein that belongs to the eIF4E-binding protein family. It contains a conserved eIF4E-binding motif (YXXXXLΦ) and competes with eIF4G for binding to eIF4E, thereby inhibiting cap-dependent translation. Phosphorylation by mTORC1 reduces its affinity for eIF4E, allowing translation to proceed. 4E-BP3 is less studied than 4E-BP1 and 4E-BP2 but is thought to play a similar regulatory role in cell growth and metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF4EBP3 Knockout HEK293 Cell Line | EDJ-KQ50807 | Human | 8637 | Details Get a Quote |
| ANKHD1-EIF4EBP3 Knockout HEK293 Cell Line | EDJ-KQ52331 | Human | 404734 | Details Get a Quote |
| EIF4EBP3 Knockout HeLa Cell Line | EDJ-KQ54963 | Human | 8637 | Details Get a Quote |
| ANKHD1-EIF4EBP3 Knockout HeLa Cell Line | EDJ-KQ60347 | Human | 404734 | Details Get a Quote |
| EIF4EBP3 Knockout A-549 Cell Line | EDJ-KQ63446 | Human | 8637 | Details Get a Quote |
| ANKHD1-EIF4EBP3 Knockout A-549 Cell Line | EDJ-KQ68814 | Human | 404734 | Details Get a Quote |
| EIF4EBP3 Knockout HCT 116 Cell Line | EDJ-KQ71914 | Human | 8637 | Details Get a Quote |
| ANKHD1-EIF4EBP3 Knockout HCT 116 Cell Line | EDJ-KQ77178 | Human | 404734 | Details Get a Quote |
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