EIF4EBP2: Eukaryotic Translation Initiation Factor 4E Binding Protein 2
A key regulator of cap-dependent translation initiation, modulating cell growth and proliferation.
Gene Information Card
| Symbol | EIF4EBP2 |
|---|---|
| Full Name | Eukaryotic Translation Initiation Factor 4E Binding Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q22.1 |
| NCBI Gene ID | 1979 ncbi.nlm.nih.gov/gene/1979 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q13542 |
| OMIM ID | 602224 |
| HGNC ID | 3289 |
| Aliases | 4E-BP2, PHASII |
Description
EIF4EBP2 encodes a member of the eukaryotic translation initiation factor 4E (eIF4E) binding protein family. The protein binds to eIF4E and inhibits cap-dependent translation by preventing the assembly of the eIF4F complex. Phosphorylation by mTOR signaling releases the inhibition, allowing translation initiation. This gene is involved in cell growth, proliferation, and synaptic plasticity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Dysregulation of EIF4EBP2 expression or phosphorylation alters cap-dependent translation, promoting oncogenic protein synthesis. | COSMIC; literature |
| Autism spectrum disorder | Altered 4E-BP2 levels affect synaptic translation and plasticity, implicated in neurodevelopmental disorders. | ClinVar; literature |
| Intellectual disability | Loss-of-function variants may impair translation regulation in neurons. | ClinVar; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Heart | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | Moderate |
| HeLa | 11.8 | Moderate |
| K562 | 9.5 | Low |
| A549 | 8.1 | Low |
| MCF7 | 7.3 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Loss of start codon, likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown functional effect |
| c.200_201del (p.Glu67fs) | frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the protein, impairing eIF4E binding and translation regulation.
Gain of Function (GOF)
Not well documented; activating mutations are rare.
Dominant Negative (DN)
Not reported for EIF4EBP2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa04150 - mTOR signaling pathway
• hsa04151 - PI3K-Akt signaling pathway
• hsa03013 - RNA transport
Protein Summary
The EIF4EBP2 protein (4E-BP2) is a 120-amino acid protein that binds to eIF4E via a conserved YXXXXLΦ motif. It inhibits cap-dependent translation by competing with eIF4G for eIF4E binding. Phosphorylation by mTORC1 at multiple sites (Thr37, Thr46, Ser65, Thr70) causes dissociation from eIF4E, enabling translation initiation. 4E-BP2 is highly expressed in the brain and plays a critical role in synaptic plasticity and memory.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF4EBP2 Knockout HEK293 Cell Line | EDJ-KQ4512 | Human | 1979 | Details Get a Quote |
| EIF4EBP2 Knockout A-549 Cell Line | EDJ-KQ27121 | Human | 1979 | Details Get a Quote |
| EIF4EBP2 Knockout HCT 116 Cell Line | EDJ-KQ27122 | Human | 1979 | Details Get a Quote |
| EIF4EBP2 Knockout HeLa Cell Line | EDJ-KQ27123 | Human | 1979 | Details Get a Quote |
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