EIF4E3: Eukaryotic Translation Initiation Factor 4E Family Member 3
A member of the EIF4E family involved in cap-dependent translation initiation and potential tumor suppression.
Gene Information Card
| Symbol | EIF4E3 |
|---|---|
| Full Name | eukaryotic translation initiation factor 4E family member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.1 |
| NCBI Gene ID | 317649 ncbi.nlm.nih.gov/gene/317649 |
| Ensembl ID | ENSG00000163631 |
| UniProt ID | Q8N5X7 |
| OMIM ID | 609896 |
| HGNC ID | 19737 |
| Aliases | eIF4E-3, FLJ20202, MGC138207 |
Description
EIF4E3 (eukaryotic translation initiation factor 4E family member 3) encodes a protein that belongs to the EIF4E family of cap-binding proteins. These proteins recognize and bind the 5' cap structure of mRNAs, playing a key role in cap-dependent translation initiation. EIF4E3 is thought to modulate translation and may function as a tumor suppressor by competing with EIF4E for cap binding, thereby regulating the translation of oncogenic mRNAs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of cap-dependent translation; EIF4E3 may act as a tumor suppressor by competing with EIF4E. | Limited; inferred from functional studies and expression data. |
| Acute myeloid leukemia (AML) | Reduced EIF4E3 expression may contribute to leukemogenesis via altered translation of pro-survival mRNAs. | Reported in some AML cohorts; further validation needed. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Bone marrow | 3.8 | Low |
| Lymph node | 2.9 | Low |
| Brain | 1.5 | Not detected |
| Heart | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.1 | Embryonic kidney; moderate expression |
| K562 | 3.5 | Chronic myeloid leukemia; low expression |
| HeLa | 2.2 | Cervical carcinoma; low expression |
| HepG2 | 1.8 | Hepatocellular carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown functional effect; rare population variant |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants near the cap-binding pocket may impair mRNA binding.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity (GO:0003743) | • RNA 7-methylguanosine cap binding (GO:0000340) |
| • regulation of translation initiation (GO:0006417) | • cytoplasm (GO:0005737) |
Pathways
• Cap-dependent translation initiation (Reactome: R-HSA-72737)
• Regulation of mRNA stability by proteins that bind AU-rich elements
Protein Summary
The EIF4E3 protein (UniProt Q8N5X7) is a 25 kDa cap-binding protein with structural similarity to EIF4E. It binds the 5' cap of mRNAs but with lower affinity than EIF4E. EIF4E3 may regulate translation by sequestering cap structures or competing with EIF4E, thereby influencing the expression of specific mRNAs involved in cell growth and survival. Its expression is enriched in testis and hematopoietic tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF4E3 Knockout HEK293 Cell Line | EDJ-KQ8873 | Human | 317649 | Details Get a Quote |
| EIF4E3 Knockout A-549 Cell Line | EDJ-KQ35193 | Human | 317649 | Details Get a Quote |
| EIF4E3 Knockout HCT 116 Cell Line | EDJ-KQ35194 | Human | 317649 | Details Get a Quote |
| EIF4E3 Knockout HeLa Cell Line | EDJ-KQ59567 | Human | 317649 | Details Get a Quote |
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