EIF3M
Eukaryotic Translation Initiation Factor 3 Subunit M
Gene Information Card
| Symbol | EIF3M |
|---|---|
| Full Name | eukaryotic translation initiation factor 3 subunit M |
| Gene Type | protein-coding |
| Chromosomal Location | 11p13 |
| NCBI Gene ID | 10480 ncbi.nlm.nih.gov/gene/10480 |
| Ensembl ID | ENSG00000149196 |
| UniProt ID | Q7L2H7 |
| OMIM ID | 609641 |
| HGNC ID | 17367 |
| Aliases | GA17, hfl-B5, PCID1, eIF3m |
Description
EIF3M encodes a subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is essential for translation initiation. The eIF3 complex binds to the 40S ribosomal subunit and promotes the formation of the 43S pre-initiation complex. EIF3M is involved in regulating protein synthesis and has been implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of translation initiation via eIF3 complex alterations | COSMIC; multiple studies |
| Colorectal cancer | Overexpression of EIF3M promotes cell proliferation | PubMed; COSMIC |
| Breast cancer | Altered expression linked to tumor progression | PubMed; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Brain | 8.5 | Low |
| Liver | 6.3 | Low |
| Heart | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | Cervical cancer cell line |
| HEK293 | 14.7 | Embryonic kidney cell line |
| A549 | 11.2 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | Rare | Unknown functional impact |
| c.100C>T | missense | Rare | Unknown functional impact |
| c.200_201del | frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations may lead to truncated protein and loss of eIF3 complex integrity.
Gain of Function (GOF)
Not well characterized; overexpression in cancer may act as a gain-of-function.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • ribosome binding |
| • cytoplasm | • eIF3 complex |
| • protein binding |
Pathways
• Eukaryotic translation initiation
• PI3K-Akt signaling pathway
• mTOR signaling pathway
Protein Summary
EIF3M is a 42 kDa protein that forms part of the eIF3 complex. It contains a PCI domain and is involved in stabilizing the eIF3 complex and promoting translation initiation. The protein is ubiquitously expressed with higher levels in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| No Data | ||||
