EIF3K
Eukaryotic Translation Initiation Factor 3 Subunit K
Gene Information Card
| Symbol | EIF3K |
|---|---|
| Full Name | eukaryotic translation initiation factor 3 subunit K |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 27335 ncbi.nlm.nih.gov/gene/27335 |
| Ensembl ID | ENSG00000105669 |
| UniProt ID | Q9UBQ5 |
| OMIM ID | 609596 |
| HGNC ID | 24668 |
| Aliases | EIF3S12, PRO1474, MSTP001, eIF3-p25 |
Description
EIF3K encodes the subunit K of eukaryotic translation initiation factor 3 (eIF3), a multiprotein complex that binds to the 40S ribosomal subunit and promotes the initiation of protein synthesis. eIF3 is involved in mRNA binding, ribosome recruitment, and scanning. EIF3K is a small subunit (25 kDa) that stabilizes the eIF3 complex and may play a role in translational control.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of translation initiation; EIF3K overexpression or mutation may alter protein synthesis in tumor cells | COSMIC; literature review |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Spleen | 11.5 | Medium |
| Bone marrow | 10.9 | Medium |
| Brain | 8.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.1 | Embryonic kidney cells |
| HeLa | 12.5 | Cervical cancer cells |
| K562 | 11.8 | Leukemia cells |
| A549 | 10.2 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | Rare | Unknown functional effect |
| c.100C>T | missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential impact on eIF3 complex stability
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • ribosome binding |
| • cytoplasm | • eukaryotic translation initiation factor 3 complex |
Pathways
• Eukaryotic Translation Initiation
• Cap-dependent Translation Initiation
• mTOR signaling
Protein Summary
EIF3K is a 25 kDa protein that forms part of the eIF3 complex. It interacts with other eIF3 subunits and contributes to the structural integrity of the complex. The protein is expressed in many tissues and is involved in the initiation phase of protein synthesis. Its precise role in disease is under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF3K Knockout HEK293 Cell Line | EDJ-KQ8766 | Human | 27335 | Details Get a Quote |
| EIF3K Knockout A-549 Cell Line | EDJ-KQ35029 | Human | 27335 | Details Get a Quote |
| EIF3K Knockout HCT 116 Cell Line | EDJ-KQ35030 | Human | 27335 | Details Get a Quote |
| EIF3K Knockout HeLa Cell Line | EDJ-KQ35031 | Human | 27335 | Details Get a Quote |
