EIF3I
Eukaryotic Translation Initiation Factor 3 Subunit I
Gene Information Card
| Symbol | EIF3I |
|---|---|
| Full Name | Eukaryotic Translation Initiation Factor 3 Subunit I |
| Gene Type | protein-coding |
| Chromosomal Location | 1p35.2 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000184611 |
| UniProt ID | Q13347 |
| OMIM ID | 603911 |
| HGNC ID | 3272 |
| Aliases | eIF3i, eIF3-p36, eIF3-beta, TRIP-1, TGF-beta receptor interacting protein 1 |
Description
EIF3I encodes a subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is essential for the initiation of protein synthesis. The protein binds to the 40S ribosomal subunit and facilitates mRNA recruitment, scanning, and start codon recognition. EIF3I also interacts with the TGF-beta receptor and may play roles in cell growth and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of EIF3I promotes translation of oncogenic mRNAs, enhancing cell proliferation and survival. | PMID: 23431171 |
| Colorectal cancer | EIF3I upregulation correlates with poor prognosis and increased metastatic potential. | PMID: 25605247 |
| Hepatocellular carcinoma | EIF3I is overexpressed and contributes to tumor growth via enhanced translation of cyclin D1. | PMID: 27485122 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 16.2 | Medium |
| Heart | 12.8 | Medium |
| Liver | 18.5 | Medium |
| Kidney | 14.1 | Medium |
| Testis | 22.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 19.7 | Embryonic kidney cell line |
| HeLa | 21.4 | Cervical cancer cell line |
| HepG2 | 20.1 | Hepatocellular carcinoma cell line |
| MCF7 | 18.9 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.1% in gnomAD | Unknown functional impact |
| c.487A>G (p.Asn163Asp) | Missense | <0.1% in gnomAD | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in EIF3I.
Gain of Function (GOF)
Overexpression in multiple cancers suggests a potential gain-of-function role in translation regulation.
Dominant Negative (DN)
No dominant-negative mutations described for EIF3I.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • RNA binding |
| • cytoplasm | • eukaryotic 43S preinitiation complex |
| • regulation of translational initiation |
Pathways
• Eukaryotic Translation Initiation (Reactome: R-HSA-72649)
• TGF-beta signaling pathway (KEGG: hsa04350)
Protein Summary
EIF3I is a 36 kDa subunit of the eIF3 complex, containing a WD40 repeat domain that mediates protein-protein interactions. It is localized in the cytoplasm and is involved in the assembly of the 43S preinitiation complex. The protein also interacts with the TGF-beta type I receptor, linking translation initiation to growth factor signaling.
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