EIF3G
Eukaryotic Translation Initiation Factor 3 Subunit G
Gene Information Card
| Symbol | EIF3G |
|---|---|
| Full Name | Eukaryotic Translation Initiation Factor 3 Subunit G |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 8667 ncbi.nlm.nih.gov/gene/8667 |
| Ensembl ID | ENSG00000104823 |
| UniProt ID | O75821 |
| OMIM ID | 603911 |
| HGNC ID | 3274 |
| Aliases | EIF3S4, eIF3-p42, eIF3g |
Description
EIF3G encodes a subunit of the eukaryotic translation initiation factor 3 (eIF3), a multiprotein complex essential for translation initiation. The eIF3 complex binds to the 40S ribosomal subunit and promotes the formation of the 43S pre-initiation complex, facilitating mRNA recruitment and scanning. EIF3G specifically interacts with the eIF3 complex and is involved in stabilizing the complex and regulating translation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of eIF3G expression alters translation of oncogenes and tumor suppressors, promoting cell proliferation and survival. | PMID: 25605274, COSMIC |
| Hepatocellular carcinoma | Overexpression of EIF3G enhances translation of cell cycle regulators, contributing to tumor growth. | PMID: 29367608 |
| Breast cancer | EIF3G upregulation correlates with poor prognosis and increased translation of pro-metastatic proteins. | PMID: 31073040 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Brain | 10.5 | Medium |
| Liver | 9.3 | Low |
| Heart | 8.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.5 | Embryonic kidney |
| HeLa | 13.2 | Cervical carcinoma |
| K562 | 11.8 | Leukemia |
| HepG2 | 10.1 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in EIF3G.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role in translation regulation.
Dominant Negative (DN)
Not described for EIF3G.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • RNA binding |
| • cytoplasmic translation | • eIF3 complex |
Pathways
• Eukaryotic Translation Initiation (Reactome R-HSA-72649)
• Cap-dependent Translation Initiation (Reactome R-HSA-72737)
Protein Summary
EIF3G is a 42 kDa protein that forms part of the eIF3 complex. It contains an RNA-binding domain and is thought to contribute to the structural integrity of the complex. The protein is ubiquitously expressed and plays a role in the recruitment of mRNAs to the ribosome. Dysregulation of EIF3G expression is associated with various cancers, where it may promote translation of growth-promoting mRNAs.
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|---|---|---|---|---|
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