EIF3CL
Eukaryotic Translation Initiation Factor 3 Subunit C Like
Gene Information Card
| Symbol | EIF3CL |
|---|---|
| Full Name | Eukaryotic Translation Initiation Factor 3 Subunit C Like |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 728489 ncbi.nlm.nih.gov/gene/728489 |
| Ensembl ID | ENSG00000204574 |
| UniProt ID | Q5TEC4 |
| OMIM ID | 618918 |
| HGNC ID | 37116 |
| Aliases | EIF3C-like, EIF3CL1 |
Description
EIF3CL (Eukaryotic Translation Initiation Factor 3 Subunit C Like) is a protein-coding gene located on chromosome 16p11.2. It encodes a subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is critical for binding to the 40S ribosomal subunit and promoting the assembly of the pre-initiation complex during protein synthesis. EIF3CL is highly similar to EIF3C and may function redundantly in translation initiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 10.2 | Medium |
| Brain | 5.1 | Low |
| Lung | 3.8 | Low |
| Liver | 2.5 | Low |
| Kidney | 3.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.5 | Moderate expression |
| HeLa | 6.2 | Low expression |
| K562 | 4.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • ribosome binding |
| • cytoplasm | • eukaryotic translation initiation factor 3 complex |
Pathways
• Eukaryotic Translation Initiation
• Ribosome
• mTOR signaling
Protein Summary
EIF3CL is a 913-amino acid protein that shares high sequence identity with EIF3C. It is a component of the eIF3 complex, which is the largest translation initiation factor and plays a central role in recruiting the 40S ribosomal subunit to mRNA. The protein contains a PCI domain and is involved in the assembly of the 43S pre-initiation complex.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF3CL Knockout HEK293 Cell Line | EDJ-KQ13269 | Human | 728689 | Details Get a Quote |
| EIF3CL Knockout A-549 Cell Line | EDJ-KQ42678 | Human | 728689 | Details Get a Quote |
| EIF3CL Knockout HCT 116 Cell Line | EDJ-KQ42679 | Human | 728689 | Details Get a Quote |
| EIF3CL Knockout HeLa Cell Line | EDJ-KQ42680 | Human | 728689 | Details Get a Quote |
