EIF3C
Eukaryotic Translation Initiation Factor 3 Subunit C
Gene Information Card
| Symbol | EIF3C |
|---|---|
| Full Name | eukaryotic translation initiation factor 3 subunit C |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 8667 ncbi.nlm.nih.gov/gene/8667 |
| Ensembl ID | ENSG00000140932 |
| UniProt ID | Q99613 |
| OMIM ID | 603916 |
| HGNC ID | 3270 |
| Aliases | EIF3S8, eIF3-p110, eIF3c |
Description
EIF3C encodes a subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is essential for cap-dependent translation initiation. The eIF3 complex binds to the 40S ribosomal subunit and facilitates mRNA recruitment, scanning, and start codon recognition. EIF3C is involved in regulating protein synthesis and cell growth, and its dysregulation is implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of EIF3C enhances translation of oncogenic mRNAs, promoting cell proliferation and tumorigenesis. | PMID: 23543788 |
| Colorectal cancer | EIF3C upregulation correlates with poor prognosis and increased translation of cyclin D1 and c-Myc. | PMID: 28723887 |
| Hepatocellular carcinoma | EIF3C promotes cell cycle progression and metastasis via enhanced translation of key oncoproteins. | PMID: 27121326 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 18.5 | High |
| Lymph node | 12.3 | Medium |
| Brain cortex | 9.8 | Medium |
| Liver | 7.2 | Low |
| Skeletal muscle | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| HEK293 | 14.8 | Embryonic kidney cell line |
| MCF7 | 12.5 | Breast cancer cell line |
| HepG2 | 11.3 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1124A>G (p.Asn375Ser) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
| c.1567C>T (p.Arg523Trp) | Missense | <0.01% | Reported in COSMIC; no known disease association |
| c.2014G>A (p.Glu672Lys) | Missense | <0.01% | Reported in COSMIC; likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in EIF3C.
Gain of Function (GOF)
Overexpression and amplification of EIF3C are observed in multiple cancers, suggesting a potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for EIF3C.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • ribosome binding |
| • cytoplasmic translation | • eIF3 complex |
| • regulation of translational initiation |
Pathways
• Eukaryotic Translation Initiation (Reactome: R-HSA-72649)
• Cap-dependent Translation Initiation (Reactome: R-HSA-72737)
• mTOR signaling (KEGG: hsa04150)
Protein Summary
EIF3C is a 110 kDa subunit of the eIF3 complex, which is the largest translation initiation factor complex. It contains a PCI (Proteasome, COP9, Initiation factor) domain and interacts with other eIF3 subunits and the 40S ribosomal subunit. EIF3C is essential for efficient cap-dependent translation and is overexpressed in several cancers, where it drives oncogenic protein synthesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF3CL Knockout HEK293 Cell Line | EDJ-KQ13269 | Human | 728689 | Details Get a Quote |
| EIF3CL Knockout A-549 Cell Line | EDJ-KQ42678 | Human | 728689 | Details Get a Quote |
| EIF3CL Knockout HCT 116 Cell Line | EDJ-KQ42679 | Human | 728689 | Details Get a Quote |
| EIF3CL Knockout HeLa Cell Line | EDJ-KQ42680 | Human | 728689 | Details Get a Quote |
