EIF1B
Eukaryotic Translation Initiation Factor 1B
Gene Information Card
| Symbol | EIF1B |
|---|---|
| Full Name | eukaryotic translation initiation factor 1B |
| Gene Type | protein-coding |
| Chromosomal Location | 3p22.1 |
| NCBI Gene ID | 10289 ncbi.nlm.nih.gov/gene/10289 |
| Ensembl ID | ENSG00000114784 |
| UniProt ID | O60739 |
| OMIM ID | 603911 |
| HGNC ID | 3251 |
| Aliases | SUI1, GC20, eIF1B, eIF-1B |
Description
EIF1B encodes a component of the eukaryotic translation initiation factor 1 complex. The protein is involved in the recognition of the start codon during translation initiation, ensuring accurate initiation of protein synthesis. It is widely expressed in various tissues and plays a role in cellular growth and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression may affect translation of oncogenes | PMID: 25691885 |
| Breast cancer | Dysregulation of translation initiation factors | PMID: 28431213 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Liver | 6.5 | Low |
| Heart | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| HEK 293 | 11.8 | Embryonic kidney cells |
| K562 | 9.5 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional effect |
| c.100C>T | Synonymous | Rare | No known effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity | • ribosome binding |
| • cytoplasm | • eukaryotic translation initiation factor 1 complex |
Pathways
• Eukaryotic translation initiation
• Cap-dependent translation initiation
Protein Summary
EIF1B is a 113-amino acid protein (12.8 kDa) that forms part of the eIF1 complex. It binds to the small ribosomal subunit and facilitates start codon selection by stabilizing the open conformation of the 40S subunit. The protein is highly conserved across eukaryotes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF1B Knockout HEK293 Cell Line | EDJ-KQ50953 | Human | 10289 | Details Get a Quote |
| EIF1B Knockout HeLa Cell Line | EDJ-KQ55370 | Human | 10289 | Details Get a Quote |
| EIF1B Knockout A-549 Cell Line | EDJ-KQ63851 | Human | 10289 | Details Get a Quote |
| EIF1B Knockout HCT 116 Cell Line | EDJ-KQ72310 | Human | 10289 | Details Get a Quote |
