DYNLL1: Dynein Light Chain LC8-Type 1
A key regulator of dynein motor complex assembly, intracellular transport, and apoptosis.
Gene Information Card
| Symbol | DYNLL1 |
|---|---|
| Full Name | Dynein Light Chain LC8-Type 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 8655 ncbi.nlm.nih.gov/gene/8655 |
| Ensembl ID | ENSG00000111011 |
| UniProt ID | P63167 |
| OMIM ID | 601562 |
| HGNC ID | 15476 |
| Aliases | LC8, DLC1, DLC8, PIN, hdlc1, DYNLL1 |
Description
DYNLL1 encodes a dynein light chain protein that is a component of the cytoplasmic dynein motor complex. It functions as a dimeric adaptor that links cargo to the dynein motor for retrograde transport along microtubules. Beyond its role in motor transport, DYNLL1 participates in apoptosis by binding to and regulating pro-apoptotic factors such as BCL2L11 (Bim) and BMF. It also interacts with transcription factors and viral proteins, influencing cell cycle, gene expression, and viral pathogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | DYNLL1 overexpression or dysregulation alters apoptosis and cell migration, promoting tumor progression. | ClinVar, COSMIC |
| Neurodegenerative disorders | Impaired axonal transport due to DYNLL1 dysfunction may contribute to neuronal death. | NCBI Gene, OMIM |
| Viral infections | DYNLL1 binds to viral proteins (e.g., rabies virus P protein, HIV-1 integrase) to facilitate viral transport and replication. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 18.5 | High |
| Heart | 15.2 | High |
| Liver | 12.8 | Medium |
| Kidney | 14.1 | High |
| Lung | 11.3 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.1 | Cervical cancer cell line |
| HEK293 | 19.8 | Embryonic kidney cells |
| K562 | 16.5 | Leukemia cell line |
| A549 | 14.2 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Glu32Lys) | Missense | <0.01% | Altered protein stability and dimerization; potential impact on cargo binding. |
| c.205C>T (p.Arg69Trp) | Missense | <0.01% | Reduced affinity for Bim; may impair apoptotic regulation. |
| c.301_303del (p.Lys101del) | In-frame deletion | <0.01% | Disrupts dynein complex assembly; loss of transport function. |
Mutation functional classification
Loss of Function (LOF)
Mutations that impair dimerization or cargo binding reduce dynein motor efficiency and disrupt retrograde transport.
Gain of Function (GOF)
Not well documented; overexpression in cancers may confer a gain-of-function by enhancing cell survival.
Dominant Negative (DN)
Mutations that produce stable but non-functional dimers can inhibit wild-type DYNLL1 activity.
View complete mutation data：
Gene Ontology (GO)
| • microtubule-based movement | • cytoplasmic dynein complex |
| • protein homodimerization activity | • apoptotic process |
| • intracellular protein transport | • binding |
Pathways
• Intracellular transport via dynein motor
• Apoptosis regulation by BCL2 family members
• HIV-1 infection cycle
Protein Summary
DYNLL1 (LC8) is a highly conserved 10 kDa light chain protein that forms stable homodimers. It binds to the intermediate chain of cytoplasmic dynein and also interacts with a wide range of cargo proteins via a short linear motif. Its dimeric structure is essential for linking cargo to the motor complex. DYNLL1 also plays a role in apoptosis by sequestering pro-apoptotic BH3-only proteins, thereby modulating cell death decisions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DYNLL1 Knockout HEK293 Cell Line | EDJ-KQ50811 | Human | 8655 | Details Get a Quote |
| DYNLL1 Knockout HeLa Cell Line | EDJ-KQ54973 | Human | 8655 | Details Get a Quote |
| DYNLL1 Knockout A-549 Cell Line | EDJ-KQ63454 | Human | 8655 | Details Get a Quote |
| DYNLL1 Knockout HCT 116 Cell Line | EDJ-KQ71922 | Human | 8655 | Details Get a Quote |
