DUSP7
Dual Specificity Phosphatase 7
Gene Information Card
| Symbol | DUSP7 |
|---|---|
| Full Name | dual specificity phosphatase 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.2 |
| NCBI Gene ID | 1849 ncbi.nlm.nih.gov/gene/1849 |
| Ensembl ID | ENSG00000164086 |
| UniProt ID | Q16829 |
| OMIM ID | 602749 |
| HGNC ID | 3070 |
| Aliases | MKP-X, PYST2, B59 |
Description
DUSP7 (dual specificity phosphatase 7) is a member of the dual specificity protein phosphatase subfamily. It inactivates MAP kinases (ERK, JNK, p38) by dephosphorylating both phosphothreonine and phosphotyrosine residues. DUSP7 is predominantly cytoplasmic and plays a role in cell proliferation, differentiation, and apoptosis regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of MAPK signaling via altered DUSP7 expression or activity | COSMIC; literature |
| Neuroblastoma | Potential tumor suppressor role through negative regulation of ERK | PubMed; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Bone marrow | 8.5 | Medium |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 8.2 | Medium expression |
| K562 | 6.7 | Medium expression |
| A549 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.511C>T (p.Arg171Trp) | Missense | Rare | Unknown functional impact |
| c.832G>A (p.Glu278Lys) | Missense | Rare | Unknown functional impact |
| c.1045_1046insA | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1045_1046insA) likely result in truncated, non-functional protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described for DUSP7.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• Negative regulation of ERK1/ERK2 cascade (Reactome: R-HSA-112409)
Protein Summary
DUSP7 encodes a 419-amino acid protein (UniProt Q16829) with a dual specificity phosphatase domain. It dephosphorylates phosphothreonine and phosphotyrosine residues within MAP kinases, thereby inactivating them. The protein is localized in the cytoplasm and is involved in fine-tuning MAPK signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP7 Knockout HEK293 Cell Line | EDJ-KQ50246 | Human | 1849 | Details Get a Quote |
| DUSP7 Knockout HeLa Cell Line | EDJ-KQ53129 | Human | 1849 | Details Get a Quote |
| DUSP7 Knockout A-549 Cell Line | EDJ-KQ61603 | Human | 1849 | Details Get a Quote |
| DUSP7 Knockout HCT 116 Cell Line | EDJ-KQ70091 | Human | 1849 | Details Get a Quote |
