DUSP5
Dual Specificity Phosphatase 5
Gene Information Card
| Symbol | DUSP5 |
|---|---|
| Full Name | Dual Specificity Phosphatase 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q25.2 |
| NCBI Gene ID | 1847 ncbi.nlm.nih.gov/gene/1847 |
| Ensembl ID | ENSG00000138166 |
| UniProt ID | Q16690 |
| OMIM ID | 603069 |
| HGNC ID | 3070 |
| Aliases | VH1, DUSP, hVH-2, DUSP5A |
Description
DUSP5 (dual specificity phosphatase 5) is a protein-coding gene that encodes a phosphatase belonging to the dual specificity phosphatase subfamily. It specifically dephosphorylates and inactivates ERK1/2 (MAPK3/MAPK1), thereby acting as a negative regulator of the MAPK/ERK signaling pathway. DUSP5 is localized in the nucleus and is induced by growth factors and stress stimuli, providing feedback control of ERK activity. Its dysregulation is implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | DUSP5 downregulation or loss leads to sustained ERK activation, promoting cell proliferation and tumorigenesis. | PMID: 21947068, COSMIC |
| Inflammatory bowel disease | Altered DUSP5 expression may disrupt ERK-mediated immune responses. | PMID: 25687214 |
| Cardiac hypertrophy | Reduced DUSP5 activity contributes to prolonged ERK signaling in cardiac cells. | PMID: 20089853 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Liver | 8.7 | Low |
| Lung | 15.2 | Medium |
| Kidney | 9.1 | Low |
| Brain | 6.4 | Low |
| Colon | 18.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.1 | High expression |
| HEK293 | 14.3 | Moderate expression |
| A549 | 19.7 | High expression |
| MCF7 | 11.2 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.1% (COSMIC) | May alter phosphatase activity |
| c.632A>G (p.Asn211Ser) | Missense | <0.1% (COSMIC) | Unknown functional effect |
| c.1-?_*?del | Deletion | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Deletions or inactivating missense mutations that reduce ERK dephosphorylation, leading to sustained MAPK signaling.
Gain of Function (GOF)
Not well documented; rare variants may increase phosphatase activity but are not clinically characterized.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• ERK signaling (Reactome: R-HSA-112409)
• Dual specificity phosphatase regulation (Reactome: R-HSA-5674135)
Protein Summary
The DUSP5 protein (UniProt Q16690) is a 384-amino acid dual specificity phosphatase with a N-terminal rhodanese-like domain and a C-terminal phosphatase domain. It specifically binds and dephosphorylates ERK1/2 on both threonine and tyrosine residues, leading to ERK inactivation. DUSP5 is predominantly nuclear and its expression is rapidly induced by ERK signaling, forming a negative feedback loop. The protein plays a critical role in controlling cell proliferation, differentiation, and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP5 Knockout HEK293 Cell Line | EDJ-KQ645 | Human | 1847 | Details Get a Quote |
| DUSP5 Knockout A-549 Cell Line | EDJ-KQ19129 | Human | 1847 | Details Get a Quote |
| DUSP5 Knockout HCT 116 Cell Line | EDJ-KQ19130 | Human | 1847 | Details Get a Quote |
| DUSP5 Knockout HeLa Cell Line | EDJ-KQ19131 | Human | 1847 | Details Get a Quote |
