DUSP29
Dual Specificity Phosphatase 29
Gene Information Card
| Symbol | DUSP29 |
|---|---|
| Full Name | dual specificity phosphatase 29 |
| Gene Type | protein coding |
| Chromosomal Location | 3p21.2 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | Q8N6M3 |
| OMIM ID | 617263 |
| HGNC ID | 33795 |
| Aliases | MKP, DUSP29, dual specificity phosphatase 29 |
Description
DUSP29 (dual specificity phosphatase 29) is a protein-coding gene that belongs to the dual specificity phosphatase family. It dephosphorylates phosphotyrosine and phosphoserine/threonine residues, modulating MAP kinase signaling pathways. DUSP29 is involved in cellular processes such as proliferation, differentiation, and apoptosis. Its expression is altered in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may affect MAPK pathway regulation | NCBI Gene, COSMIC |
| Colorectal cancer | Potential tumor suppressor role via phosphatase activity | COSMIC, ClinVar |
| Inflammatory bowel disease | Dysregulation of DUSP29 expression linked to inflammation | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Spleen | 6.1 | Low |
| Bone marrow | 4.7 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Embryonic kidney cells |
| HeLa | 7.2 | Cervical cancer cells |
| MCF7 | 5.6 | Breast cancer cells |
| HCT116 | 4.3 | Colorectal cancer cells |
| K562 | 3.1 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.215G>A | missense | 0.02% | p.Arg72Gln; potential loss of function |
| c.487C>T | nonsense | 0.01% | p.Gln163*; premature truncation |
| c.632A>G | missense | 0.03% | p.Asn211Ser; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense and missense mutations that reduce phosphatase activity or protein stability.
Gain of Function (GOF)
Not reported in DUSP29.
Dominant Negative (DN)
Not reported in DUSP29.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5673001)
• Negative regulation of MAPK cascade (KEGG: hsa04010)
Protein Summary
DUSP29 encodes a dual specificity phosphatase that dephosphorylates both phosphotyrosine and phosphoserine/threonine residues. It negatively regulates MAP kinase signaling by inactivating ERK, JNK, and p38. The protein is localized in the nucleus and cytoplasm and is expressed in testis, lymphoid tissues, and various cancer cell lines. Mutations in DUSP29 are rare but may contribute to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP29 Knockout HEK293 Cell Line | EDJ-KQ12450 | Human | 338599 | Details Get a Quote |
| DUSP29 Knockout HeLa Cell Line | EDJ-KQ59616 | Human | 338599 | Details Get a Quote |
| DUSP29 Knockout A-549 Cell Line | EDJ-KQ68081 | Human | 338599 | Details Get a Quote |
| DUSP29 Knockout HCT 116 Cell Line | EDJ-KQ76456 | Human | 338599 | Details Get a Quote |
