DUSP28
Dual Specificity Phosphatase 28
Gene Information Card
| Symbol | DUSP28 |
|---|---|
| Full Name | dual specificity phosphatase 28 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 285193 ncbi.nlm.nih.gov/gene/285193 |
| Ensembl ID | ENSG00000163083 |
| UniProt ID | Q8N6M0 |
| OMIM ID | - |
| HGNC ID | 28738 |
| Aliases | VHP, DSP28 |
Description
DUSP28 (dual specificity phosphatase 28) is a protein-coding gene that encodes a member of the dual specificity phosphatase (DUSP) family. The encoded protein dephosphorylates phosphotyrosine and phosphoserine/phosphothreonine residues, and is involved in the negative regulation of MAPK signaling pathways. DUSP28 is implicated in cellular proliferation, differentiation, and stress response.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression of DUSP28 promotes cell proliferation and tumor growth via MAPK pathway modulation | PMID: 25605247 |
| Colorectal cancer | DUSP28 upregulation correlates with poor prognosis and increased metastatic potential | PMID: 27323851 |
| Breast cancer | DUSP28 expression associated with tumor progression and resistance to therapy | PMID: 29351285 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 4.2 | Low |
| Kidney | 3.8 | Low |
| Testis | 2.1 | Low |
| Lung | 1.5 | Not detected |
| Brain | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 5.1 | Hepatocellular carcinoma cell line |
| MCF7 | 3.4 | Breast cancer cell line |
| HCT116 | 2.9 | Colorectal carcinoma cell line |
| A549 | 1.2 | Lung adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.187C>T (p.Arg63Trp) | Missense | <0.01% | Unknown functional effect |
| c.244G>A (p.Gly82Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5687128)
• Negative regulation of MAPK cascade (GO:0043409)
Protein Summary
DUSP28 is a small dual specificity phosphatase (approx. 20 kDa) that localizes to the cytoplasm. It dephosphorylates both phosphotyrosine and phosphoserine/threonine residues on MAP kinases, thereby negatively regulating MAPK signaling. DUSP28 is expressed at low levels in normal tissues but is upregulated in several cancers, where it may contribute to tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP28 Knockout HEK293 Cell Line | EDJ-KQ13229 | Human | 285193 | Details Get a Quote |
| DUSP28 Knockout A-549 Cell Line | EDJ-KQ42608 | Human | 285193 | Details Get a Quote |
| DUSP28 Knockout HCT 116 Cell Line | EDJ-KQ42609 | Human | 285193 | Details Get a Quote |
| DUSP28 Knockout HeLa Cell Line | EDJ-KQ42610 | Human | 285193 | Details Get a Quote |
