DUSP23
Dual Specificity Phosphatase 23
Gene Information Card
| Symbol | DUSP23 |
|---|---|
| Full Name | dual specificity phosphatase 23 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q23.2 |
| NCBI Gene ID | 54935 ncbi.nlm.nih.gov/gene/54935 |
| Ensembl ID | ENSG00000158716 |
| UniProt ID | Q9BVJ7 |
| OMIM ID | 611465 |
| HGNC ID | 16263 |
| Aliases | VHX, LDP-3, MKP-23 |
Description
DUSP23 (dual specificity phosphatase 23) is a protein-coding gene that encodes a member of the dual specificity protein phosphatase subfamily. The encoded protein dephosphorylates phosphotyrosine and phosphoserine/threonine residues, regulating MAPK signaling pathways. It is involved in cell proliferation, differentiation, and apoptosis. DUSP23 is also known as VHX, LDP-3, and MKP-23.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | DUSP23 overexpression may promote tumor growth via MAPK pathway dysregulation | PMID: 21502569 |
| Prostate cancer | Altered DUSP23 expression linked to androgen receptor signaling | PMID: 23159787 |
| Hepatocellular carcinoma | DUSP23 upregulation associated with poor prognosis | PMID: 28031556 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Heart | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 10.5 | Moderate expression |
| MCF7 | 8.9 | Moderate expression |
| HepG2 | 7.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.157C>T (p.Arg53Trp) | Missense | <0.01% | Unknown functional impact |
| c.208G>A (p.Glu70Lys) | Missense | <0.01% | Potential loss of phosphatase activity |
Mutation functional classification
Loss of Function (LOF)
p.Glu70Lys may reduce catalytic activity based on structural homology.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • MAP kinase phosphatase activity |
| • protein dephosphorylation | • negative regulation of MAPK cascade |
| • cytoplasm | • nucleus |
Pathways
• MAPK signaling pathway (Reactome R-HSA-5673001)
• ERK signaling (KEGG hsa04010)
Protein Summary
DUSP23 is a 176-amino acid dual specificity phosphatase that contains a conserved catalytic domain. It dephosphorylates phosphotyrosine and phosphoserine/threonine residues, preferentially targeting MAP kinases such as ERK and p38. The protein is localized in the cytoplasm and nucleus, and its expression is regulated during cell cycle. DUSP23 plays a role in modulating cell growth and stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP23 Knockout HEK293 Cell Line | EDJ-KQ13227 | Human | 54935 | Details Get a Quote |
| DUSP23 Knockout A-549 Cell Line | EDJ-KQ42605 | Human | 54935 | Details Get a Quote |
| DUSP23 Knockout HCT 116 Cell Line | EDJ-KQ42606 | Human | 54935 | Details Get a Quote |
| DUSP23 Knockout HeLa Cell Line | EDJ-KQ42607 | Human | 54935 | Details Get a Quote |
