DUSP2 (Dual Specificity Phosphatase 2)
A key regulator of MAPK signaling with implications in inflammation, immunity, and cancer
Gene Information Card
| Symbol | DUSP2 |
|---|---|
| Full Name | Dual specificity phosphatase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 1844 ncbi.nlm.nih.gov/gene/1844 |
| Ensembl ID | ENSG00000158050 |
| UniProt ID | Q05923 |
| OMIM ID | 603068 |
| HGNC ID | 3070 |
| Aliases | PAC1, PAC-1, MKP-2 |
Description
DUSP2 (dual specificity phosphatase 2) encodes a protein that belongs to the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSP2 specifically dephosphorylates and inactivates ERK1/2 and p38 MAPK, negatively regulating MAPK signaling pathways. It is involved in cellular proliferation, differentiation, apoptosis, and immune responses. DUSP2 expression is induced by stress and growth factors, and its dysregulation has been linked to various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | DUSP2 acts as a tumor suppressor by negatively regulating ERK and p38 MAPK pathways; loss of DUSP2 expression leads to increased cell proliferation and survival. | Multiple studies show reduced DUSP2 expression in various cancers (e.g., breast, lung, colorectal) correlating with poor prognosis (COSMIC, literature). |
| Inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease) | DUSP2 regulates inflammatory cytokine production by controlling MAPK activity in immune cells; altered expression contributes to chronic inflammation. | Evidence from animal models and patient samples (NCBI Gene, OMIM). |
| Immune disorders | DUSP2 modulates T cell and macrophage function; dysregulation can affect immune responses and autoimmunity. | Functional studies in immune cells (UniProt, literature). |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | Low | Low expression |
| Lymph node | Low | Low expression |
| Spleen | Low | Low expression |
| Blood | Low | Low expression |
| Lung | Low | Low expression |
| Liver | Low | Low expression |
| Kidney | Low | Low expression |
| Brain | Low | Low expression |
| Heart | Low | Low expression |
| Muscle | Low | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | Low | Chronic myeloid leukemia cell line |
| MCF7 | Low | Breast cancer cell line |
| A549 | Low | Lung cancer cell line |
| HeLa | Low | Cervical cancer cell line |
| HEK293 | Low | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | Rare | Potential loss of start codon, leading to truncated protein |
| c.100C>T (p.Arg34Ter) | Nonsense | Rare | Premature stop codon, likely loss of function |
| c.200A>G (p.Asn67Ser) | Missense | Rare | Unknown effect, possibly damaging |
| c.300G>A (p.Met100Ile) | Missense | Rare | Unknown effect, possibly damaging |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations (e.g., nonsense, frameshift) lead to reduced DUSP2 activity, resulting in hyperactive MAPK signaling, promoting cell proliferation and survival, contributing to tumorigenesis.
Gain of Function (GOF)
Gain-of-function mutations are rare and not well-documented; potential overexpression could lead to excessive MAPK inhibition, affecting normal cellular processes.
Dominant Negative (DN)
Dominant-negative mutations may occur if a mutant DUSP2 protein retains binding to substrates but lacks phosphatase activity, thereby blocking access of wild-type DUSP2 to its targets.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • protein serine/threonine phosphatase activity |
| • MAP kinase phosphatase activity | • protein binding |
| • dephosphorylation | • MAPK cascade |
| • regulation of cell proliferation | • apoptotic process |
| • immune response | • inflammatory response |
Pathways
• MAPK signaling pathway
• ErbB signaling pathway
• T cell receptor signaling pathway
• B cell receptor signaling pathway
• Fc epsilon RI signaling pathway
• Toll-like receptor signaling pathway
Protein Summary
The DUSP2 protein, also known as PAC1 or MKP-2, is a dual specificity phosphatase that dephosphorylates both phosphoserine/threonine and phosphotyrosine residues on its substrates. It specifically inactivates ERK1/2 and p38 MAPK, thereby negatively regulating MAPK signaling cascades. DUSP2 is localized in the nucleus and is induced by various stimuli, including growth factors and cellular stress. It plays a critical role in controlling cell proliferation, differentiation, apoptosis, and immune responses. Altered DUSP2 expression or function is associated with cancer progression and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP2 Knockout HEK293 Cell Line | EDJ-KQ642 | Human | 1844 | Details Get a Quote |
| DUSP29 Knockout HEK293 Cell Line | EDJ-KQ12450 | Human | 338599 | Details Get a Quote |
| DUSP21 Knockout HEK293 Cell Line | EDJ-KQ13224 | Human | 63904 | Details Get a Quote |
| DUSP22 Knockout HEK293 Cell Line | EDJ-KQ13225 | Human | 56940 | Details Get a Quote |
| DUSP23 Knockout HEK293 Cell Line | EDJ-KQ13227 | Human | 54935 | Details Get a Quote |
| DUSP26 Knockout HEK293 Cell Line | EDJ-KQ13228 | Human | 78986 | Details Get a Quote |
| DUSP28 Knockout HEK293 Cell Line | EDJ-KQ13229 | Human | 285193 | Details Get a Quote |
| DUSP2 Knockout HCT 116 Cell Line | EDJ-KQ19121 | Human | 1844 | Details Get a Quote |
| DUSP2 Knockout HeLa Cell Line | EDJ-KQ19122 | Human | 1844 | Details Get a Quote |
| DUSP22 Knockout HeLa Cell Line | EDJ-KQ41377 | Human | 56940 | Details Get a Quote |
| DUSP22 Knockout A-549 Cell Line | EDJ-KQ42603 | Human | 56940 | Details Get a Quote |
| DUSP22 Knockout HCT 116 Cell Line | EDJ-KQ42604 | Human | 56940 | Details Get a Quote |
| DUSP23 Knockout A-549 Cell Line | EDJ-KQ42605 | Human | 54935 | Details Get a Quote |
| DUSP23 Knockout HCT 116 Cell Line | EDJ-KQ42606 | Human | 54935 | Details Get a Quote |
| DUSP23 Knockout HeLa Cell Line | EDJ-KQ42607 | Human | 54935 | Details Get a Quote |
