DUSP19
Dual Specificity Phosphatase 19
Gene Information Card
| Symbol | DUSP19 |
|---|---|
| Full Name | dual specificity phosphatase 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q32.1 |
| NCBI Gene ID | 142679 ncbi.nlm.nih.gov/gene/142679 |
| Ensembl ID | ENSG00000162961 |
| UniProt ID | Q8WUI2 |
| OMIM ID | 611437 |
| HGNC ID | 23924 |
| Aliases | SKRP1, DUSP19, LMWDSP5 |
Description
DUSP19 (dual specificity phosphatase 19) encodes a member of the dual-specificity phosphatase (DUSP) family. The protein dephosphorylates phosphoserine, phosphothreonine, and phosphotyrosine residues. It specifically inactivates MAP kinases, particularly JNK and p38, by dephosphorylating critical threonine and tyrosine residues. DUSP19 is involved in regulating stress-activated protein kinase signaling and plays roles in inflammation, cell proliferation, and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | DUSP19 overexpression may modulate JNK/p38 signaling, affecting tumor growth and apoptosis | COSMIC, literature |
| Inflammatory diseases | Regulation of JNK/p38 pathways influences cytokine production and immune response | NCBI, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 5.2 | Low |
| Brain | 2.1 | Low |
| Liver | 8.7 | Medium |
| Lung | 4.3 | Low |
| Spleen | 6.8 | Medium |
| Testis | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Moderate expression |
| HeLa | 9.1 | Moderate expression |
| HepG2 | 15.6 | High expression |
| A549 | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | missense | 0.01% (gnomAD) | Unknown functional impact |
| c.544G>A (p.Gly182Arg) | missense | 0.005% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • MAP kinase phosphatase activity |
| • protein dephosphorylation | • JNK cascade |
| • negative regulation of MAP kinase activity | • cytoplasm |
Pathways
• MAPK signaling pathway
• JNK signaling pathway
• p38 MAPK signaling pathway
Protein Summary
DUSP19 is a 184-amino acid dual-specificity phosphatase that dephosphorylates phosphotyrosine and phosphoserine/threonine residues. It specifically targets and inactivates JNK and p38 MAP kinases, thereby negatively regulating stress-activated protein kinase signaling. The protein is localized in the cytoplasm and is expressed in multiple tissues, with highest levels in liver and spleen. DUSP19 plays a role in modulating inflammatory responses and cell survival.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP19 Knockout HEK293 Cell Line | EDJ-KQ10124 | Human | 142679 | Details Get a Quote |
| DUSP19 Knockout HCT 116 Cell Line | EDJ-KQ35990 | Human | 142679 | Details Get a Quote |
| DUSP19 Knockout A-549 Cell Line | EDJ-KQ37223 | Human | 142679 | Details Get a Quote |
| DUSP19 Knockout HeLa Cell Line | EDJ-KQ37225 | Human | 142679 | Details Get a Quote |
