DUSP15
Dual Specificity Phosphatase 15
Gene Information Card
| Symbol | DUSP15 |
|---|---|
| Full Name | dual specificity phosphatase 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 128853 ncbi.nlm.nih.gov/gene/128853 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9H1R2 |
| OMIM ID | 617592 |
| HGNC ID | 14622 |
| Aliases | VHY, FLJ22531 |
Description
DUSP15 (dual specificity phosphatase 15) is a protein-coding gene that encodes a member of the dual-specificity phosphatase (DUSP) family. The encoded protein dephosphorylates phosphotyrosine and phosphoserine/phosphothreonine residues, and is involved in regulating MAPK signaling pathways. DUSP15 is expressed in multiple tissues, with highest levels in testis and brain. It has been implicated in neurodevelopmental processes and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | DUSP15 overexpression may modulate MAPK/ERK signaling, promoting tumor cell proliferation | COSMIC; PMID: 23535731 |
| Colorectal cancer | Altered DUSP15 expression linked to poor prognosis via dysregulated phosphatase activity | COSMIC; PMID: 25344691 |
| Neurodevelopmental disorders | Potential role in neuronal differentiation; mutations may disrupt synaptic signaling | ClinVar; PMID: 28492532 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 4.1 | Low |
| Liver | 2.0 | Not detected |
| Kidney | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.2 | Moderate expression |
| HeLa | 4.8 | Low expression |
| MCF7 | 7.1 | Moderate expression |
| A549 | 5.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | 0.02% | Unknown; predicted damaging by SIFT |
| c.454G>A (p.Glu152Lys) | Missense | 0.01% | Unknown; may affect phosphatase activity |
| c.123_124insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.123_124insA) predicted to truncate the protein and abolish phosphatase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not documented for DUSP15.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • MAP kinase phosphatase activity |
| • dephosphorylation | • negative regulation of MAPK cascade |
| • cytoplasm | • nucleus |
Pathways
• MAPK signaling pathway
• ERK signaling cascade
Protein Summary
DUSP15 encodes a 185-amino acid dual-specificity phosphatase with a conserved catalytic domain. It dephosphorylates both phosphotyrosine and phosphoserine/phosphothreonine residues, preferentially targeting MAP kinases such as ERK. The protein is localized in the cytoplasm and nucleus, and is involved in negative regulation of cell proliferation and differentiation. Its expression is enriched in testis and brain, suggesting roles in spermatogenesis and neurodevelopment.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP15 Knockout HEK293 Cell Line | EDJ-KQ9199 | Human | 128853 | Details Get a Quote |
| DUSP15 Knockout HeLa Cell Line | EDJ-KQ58252 | Human | 128853 | Details Get a Quote |
| DUSP15 Knockout A-549 Cell Line | EDJ-KQ66740 | Human | 128853 | Details Get a Quote |
| DUSP15 Knockout HCT 116 Cell Line | EDJ-KQ75151 | Human | 128853 | Details Get a Quote |
