DUSP14
Dual Specificity Phosphatase 14
Gene Information Card
| Symbol | DUSP14 |
|---|---|
| Full Name | dual specificity phosphatase 14 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 11072 ncbi.nlm.nih.gov/gene/11072 |
| Ensembl ID | ENSG00000108821 |
| UniProt ID | O95147 |
| OMIM ID | 604832 |
| HGNC ID | 3075 |
| Aliases | MKP6, MKP-6, DSP6 |
Description
DUSP14 (dual specificity phosphatase 14) encodes a member of the dual specificity protein phosphatase subfamily. This phosphatase dephosphorylates phosphotyrosine and phosphoserine/threonine residues, negatively regulating MAP kinase (MAPK) signaling cascades, particularly ERK, JNK, and p38. DUSP14 is involved in immune regulation, cell proliferation, and apoptosis. It is also known as MKP6 (MAP kinase phosphatase 6).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | DUSP14 overexpression suppresses MAPK signaling, reducing tumor growth | PMID: 25605274 |
| Gastric cancer | Downregulation of DUSP14 correlates with poor prognosis and increased ERK activation | PMID: 27158335 |
| Type 2 diabetes | DUSP14 regulates insulin signaling via JNK dephosphorylation | PMID: 20628055 |
| Rheumatoid arthritis | DUSP14 modulates inflammatory cytokine production in T cells | PMID: 23300459 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Medium |
| Heart | 6.1 | Low |
| Brain | 4.5 | Low |
| Lung | 9.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.1 | Hepatocellular carcinoma cell line |
| HEK293 | 11.4 | Embryonic kidney cells |
| Jurkat | 7.8 | T-cell leukemia line |
| HeLa | 6.3 | Cervical cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.314A>G (p.Tyr105Cys) | Missense | <0.01% | Reduced phosphatase activity; associated with immune dysregulation |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Loss of function; impaired JNK dephosphorylation |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function; no protein expression |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Tyr105Cys, p.Arg163Trp) reduce catalytic activity, leading to sustained MAPK signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in DUSP14.
Dominant Negative (DN)
Not described for DUSP14.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • MAP kinase phosphatase activity |
| • protein serine/threonine phosphatase activity | • negative regulation of MAPK cascade |
| • JNK dephosphorylation | • ERK dephosphorylation |
| • p38 dephosphorylation | • immune system process |
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• Negative regulation of MAPK cascade (Reactome: R-HSA-5675220)
• Immune system (Reactome: R-HSA-168256)
Protein Summary
DUSP14 is a 198-amino acid dual specificity phosphatase that dephosphorylates both phosphotyrosine and phosphoserine/threonine residues on MAP kinases (ERK, JNK, p38). It contains a conserved catalytic domain and a MAP kinase binding motif. The protein localizes to the cytoplasm and nucleus, and its expression is induced by stress stimuli. DUSP14 plays a key role in attenuating inflammatory and proliferative signals.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP14 Knockout HEK293 Cell Line | EDJ-KQ7270 | Human | 11072 | Details Get a Quote |
| DUSP14 Knockout A-549 Cell Line | EDJ-KQ30908 | Human | 11072 | Details Get a Quote |
| DUSP14 Knockout HCT 116 Cell Line | EDJ-KQ32290 | Human | 11072 | Details Get a Quote |
| DUSP14 Knockout HeLa Cell Line | EDJ-KQ32291 | Human | 11072 | Details Get a Quote |
