DUSP13A
Dual Specificity Phosphatase 13A
Gene Information Card
| Symbol | DUSP13A |
|---|---|
| Full Name | Dual Specificity Phosphatase 13A |
| Gene Type | protein-coding |
| Chromosomal Location | 10q22.2 |
| NCBI Gene ID | 51207 ncbi.nlm.nih.gov/gene/51207 |
| Ensembl ID | ENSG00000148848 |
| UniProt ID | Q6B8I1 |
| OMIM ID | 612014 |
| HGNC ID | 30615 |
| Aliases | DUSP13, TMDP, SKRP3, BEDP |
Description
DUSP13A encodes a member of the dual specificity protein phosphatase subfamily, which dephosphorylates both phosphoserine/threonine and phosphotyrosine residues. This phosphatase is testis-specific and negatively regulates MAP kinase signaling, particularly JNK and p38 pathways. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | Altered phosphatase activity affecting spermatogenesis | PMID: 19088126 |
| Testicular germ cell tumors | Dysregulation of DUSP13A expression | PMID: 23358650 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Fallopian tube | 0.3 | Low |
| Prostate | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Seminoma cell line (TCam-2) | 8.1 | Testicular origin |
| HEK293 | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Cys) | Missense | <0.01% | Unknown functional effect |
| c.632A>G (p.Tyr211Cys) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not reported in literature
Gain of Function (GOF)
Not reported in literature
Dominant Negative (DN)
Not reported in literature
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5687128)
• Negative regulation of JNK cascade (Reactome: R-HSA-450341)
Protein Summary
DUSP13A is a 198-amino acid dual specificity phosphatase with a conserved catalytic domain. It specifically dephosphorylates and inactivates MAP kinases JNK and p38, but not ERK. The protein is predominantly expressed in testis and plays a role in spermatogenesis. Its activity is regulated by substrate binding and subcellular localization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP13A Knockout HEK293 Cell Line | EDJ-KQ13223 | Human | 128854680 | Details Get a Quote |
| DUSP13A Knockout A-549 Cell Line | EDJ-KQ42600 | Human | 128854680 | Details Get a Quote |
| DUSP13A Knockout HCT 116 Cell Line | EDJ-KQ42601 | Human | 128854680 | Details Get a Quote |
| DUSP13A Knockout HeLa Cell Line | EDJ-KQ42602 | Human | 128854680 | Details Get a Quote |
