DUSP11 Gene: Dual Specificity Phosphatase 11 – Function, Expression, and Disease Relevance

DUSP11 (dual specificity phosphatase 11) encodes a member of the dual-specificity phosphatase family that dephosphorylates both phosphotyrosine and phosphoserine/threonine residues. The protein is localized to the nucleus and interacts with RNA and ribonucleoprotein complexes, functioning as an RNA 5'-triphosphatase involved in RNA processing, including the removal of 5'-triphosphate groups from RNA molecules. It plays a role in the regulation of RNA metabolism, innate immune responses, and may influence viral RNA sensing.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• RNA processing (R-HSA-8953854)

• Innate immune system (R-HSA-168249)

• RIG-I/MDA5 mediated induction of IFN-alpha/beta (R-HSA-936440)

DUSP11 is a 330-amino acid dual-specificity phosphatase with a conserved active site motif (HCxxGxxR). It localizes to the nucleus and functions as an RNA 5'-triphosphatase, removing the 5'-triphosphate from RNA molecules, which is critical for RNA processing and for modulating innate immune recognition of viral RNA by RIG-I-like receptors. The protein interacts with RNA and ribonucleoprotein complexes, and its expression is enriched in lymphoid tissues and testis. DUSP11 has been implicated in cellular responses to viral infection and in cancer through altered RNA metabolism.