DUSP10 (Dual Specificity Phosphatase 10)
A MAP kinase phosphatase regulating stress response and inflammation
Gene Information Card
| Symbol | DUSP10 |
|---|---|
| Full Name | Dual Specificity Phosphatase 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q41 |
| NCBI Gene ID | 11221 ncbi.nlm.nih.gov/gene/11221 |
| Ensembl ID | ENSG00000143507 |
| UniProt ID | Q9Y6W6 |
| OMIM ID | 604749 |
| HGNC ID | 3070 |
| Aliases | MKP-5, MKP5 |
Description
DUSP10 (dual specificity phosphatase 10) encodes a member of the mitogen-activated protein (MAP) kinase phosphatase family. It dephosphorylates both phosphoserine/threonine and phosphotyrosine residues within MAP kinases, specifically targeting p38 and JNK, thereby negatively regulating stress-activated protein kinase signaling. DUSP10 is involved in immune response, inflammation, and cellular stress adaptation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Reduced DUSP10 expression correlates with increased p38/JNK activity and tumor progression | PMID: 19690332 |
| Inflammatory bowel disease | DUSP10 deficiency exacerbates intestinal inflammation via enhanced JNK signaling | PMID: 16920922 |
| Rheumatoid arthritis | DUSP10 downregulation in synovial fibroblasts promotes inflammatory cytokine production | PMID: 21930896 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skeletal muscle | 12.5 | Medium |
| Heart | 8.3 | Medium |
| Liver | 4.1 | Low |
| Lung | 6.7 | Medium |
| Kidney | 5.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.2 | Cervical carcinoma |
| HEK 293 | 8.9 | Embryonic kidney |
| HepG2 | 5.3 | Hepatocellular carcinoma |
| A549 | 7.1 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Unknown functional impact |
| c.1282G>A (p.Glu428Lys) | Missense | <0.01% | Potential loss of phosphatase activity |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the catalytic domain may impair phosphatase activity, leading to sustained MAPK signaling.
Gain of Function (GOF)
Not reported in literature.
Dominant Negative (DN)
Not described for DUSP10.
View complete mutation data：
Gene Ontology (GO)
| • MAP kinase phosphatase activity | • protein tyrosine phosphatase activity |
| • protein serine/threonine phosphatase activity | • negative regulation of JNK cascade |
| • negative regulation of p38MAPK cascade | • inflammatory response |
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• p38 MAPK signaling
• JNK signaling
Protein Summary
DUSP10 (MKP-5) is a 482-amino acid dual specificity phosphatase that selectively inactivates p38 and JNK MAP kinases. It contains an N-terminal MAP kinase-binding domain and a C-terminal catalytic phosphatase domain. The protein is predominantly cytoplasmic but can translocate to the nucleus upon stress. DUSP10 plays a critical role in modulating immune and inflammatory responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP10 Knockout HEK293 Cell Line | EDJ-KQ640 | Human | 11221 | Details Get a Quote |
| DUSP10 Knockout A-549 Cell Line | EDJ-KQ19115 | Human | 11221 | Details Get a Quote |
| DUSP10 Knockout HCT 116 Cell Line | EDJ-KQ19116 | Human | 11221 | Details Get a Quote |
| DUSP10 Knockout HeLa Cell Line | EDJ-KQ19117 | Human | 11221 | Details Get a Quote |
