DTD1 (D-Tyrosyl-tRNA Deacylase 1)
A key enzyme in translational quality control, preventing the incorporation of D-amino acids into proteins.
Gene Information Card
| Symbol | DTD1 |
|---|---|
| Full Name | D-Tyrosyl-tRNA Deacylase 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 20p11.23 |
| NCBI Gene ID | 92675 ncbi.nlm.nih.gov/gene/92675 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q8TEA8 |
| OMIM ID | 611248 |
| HGNC ID | 26147 |
| Aliases | C20orf88, DTD, DTYD, D-Tyr-tRNA(Tyr) deacylase |
Description
The DTD1 gene encodes D-tyrosyl-tRNA deacylase 1, an enzyme that hydrolyzes D-tyrosyl-tRNA(Tyr) and other D-aminoacyl-tRNAs, thereby preventing the incorporation of D-amino acids into nascent proteins. This quality control mechanism is essential for maintaining proteome fidelity and cellular homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered DTD1 expression may disrupt translational fidelity, contributing to tumorigenesis. | NCBI Gene, COSMIC |
| Neurodegenerative disorders | D-amino acid accumulation due to DTD1 dysfunction may impair neuronal function. | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Medium |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
| Heart | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | High expression |
| HeLa | 7.3 | Moderate expression |
| HepG2 | 5.9 | Low expression |
| K562 | 4.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Potential loss of deacylase activity |
| c.454G>A (p.Gly152Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg113Trp) may reduce or abolish DTD1 enzymatic activity, leading to D-amino acid misincorporation.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • D-tyrosyl-tRNA deacylase activity | • tRNA binding |
| • cytoplasm | • protein quality control |
| • translation |
Pathways
• tRNA aminoacylation
• Protein quality control
• D-amino acid metabolism
Protein Summary
DTD1 is a 20 kDa cytoplasmic enzyme that specifically deacylates D-tyrosyl-tRNA(Tyr) and other D-aminoacyl-tRNAs. It forms a homodimer and is conserved across species. The protein contains a DTD-like domain essential for catalytic activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DTD1 Knockout HEK293 Cell Line | EDJ-KQ11022 | Human | 92675 | Details Get a Quote |
| DTD1 Knockout HeLa Cell Line | EDJ-KQ37612 | Human | 92675 | Details Get a Quote |
| DTD1 Knockout A-549 Cell Line | EDJ-KQ38914 | Human | 92675 | Details Get a Quote |
| DTD1 Knockout HCT 116 Cell Line | EDJ-KQ38915 | Human | 92675 | Details Get a Quote |
