DSTN (Destrin) - Actin Depolymerizing Factor in Cytoskeletal Dynamics
Comprehensive gene resource for DSTN, encoding destrin, a key regulator of actin filament dynamics, with implications in cancer, immune function, and development.
Gene Information Card
| Symbol | DSTN |
|---|---|
| Full Name | destrin, actin depolymerizing factor |
| Gene Type | protein coding |
| Chromosomal Location | 20p12.1 |
| NCBI Gene ID | 11034 ncbi.nlm.nih.gov/gene/11034 |
| Ensembl ID | ENSG00000125868 |
| UniProt ID | P60981 |
| OMIM ID | 602373 |
| HGNC ID | 10950 |
| Aliases | ADF, DSTN, actin depolymerizing factor |
Description
The DSTN gene encodes destrin, a member of the actin depolymerizing factor (ADF)/cofilin family. Destrin binds to actin monomers and filaments, promoting severing and depolymerization of actin filaments in a pH-dependent manner. This activity is crucial for actin cytoskeleton remodeling, cell motility, and intracellular transport. DSTN is widely expressed and plays roles in development, immune response, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered DSTN expression affects actin dynamics, promoting cell migration and invasion. | COSMIC: DSTN mutations and expression changes observed in multiple cancer types. |
| Immunodeficiency (potential) | DSTN regulates actin dynamics in immune cells; defects may impair immune function. | UniProt: DSTN involved in T-cell activation and migration. |
| Developmental disorders (potential) | Actin dynamics are critical for development; DSTN mutations may disrupt morphogenesis. | OMIM: No direct disease association, but functional relevance inferred. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Blood | High | High |
| Spleen | High | High |
| Bone Marrow | High | High |
| Lymph Node | High | High |
| Brain | Medium | Medium |
| Liver | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | High | Cancer cell line with high DSTN expression. |
| HeLa (cervical cancer) | Medium | Moderate expression. |
| A549 (lung cancer) | Medium | Moderate expression. |
| HUVEC (endothelial) | Medium | Endothelial cells express DSTN. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Gly41Gly) | Synonymous | Rare | No known effect. |
| c.456A>G (p.Glu152Gly) | Missense | Rare | Potential impact on actin binding. |
| c.789T>C (p.Ser263Pro) | Missense | Rare | May affect protein stability. |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in DSTN are not well characterized; however, reduced expression is linked to impaired actin dynamics and cell motility defects.
Gain of Function (GOF)
Gain-of-function mutations are rare; overexpression of DSTN is observed in some cancers, potentially enhancing cell invasion.
Dominant Negative (DN)
No dominant-negative mutations have been reported for DSTN.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • actin filament depolymerization |
| • actin filament severing | • cytoskeleton organization |
| • cell motility |
Pathways
• Regulation of actin cytoskeleton
• Fc gamma R-mediated phagocytosis
• Chemokine signaling pathway
Protein Summary
Destrin (also known as ADF) is a small actin-binding protein that severs and depolymerizes actin filaments, playing a central role in actin dynamics. It is regulated by pH and phosphorylation. Destrin is essential for cell motility, cytokinesis, and intracellular trafficking. Its expression is ubiquitous, with high levels in hematopoietic tissues. Dysregulation of DSTN is implicated in cancer metastasis and immune dysfunction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DSTN Knockout HEK293 Cell Line | EDJ-KQ51031 | Human | 11034 | Details Get a Quote |
| DSTN Knockout HeLa Cell Line | EDJ-KQ55551 | Human | 11034 | Details Get a Quote |
| DSTN Knockout A-549 Cell Line | EDJ-KQ64045 | Human | 11034 | Details Get a Quote |
| DSTN Knockout HCT 116 Cell Line | EDJ-KQ72495 | Human | 11034 | Details Get a Quote |
