DRG2: Developmentally Regulated GTP-Binding Protein 2
A comprehensive biomedical resource for DRG2, covering gene annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | DRG2 |
|---|---|
| Full Name | Developmentally Regulated GTP-Binding Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.1 |
| NCBI Gene ID | 1819 ncbi.nlm.nih.gov/gene/1819 |
| Ensembl ID | ENSG00000108591 |
| UniProt ID | P55040 |
| OMIM ID | 602986 |
| HGNC ID | 3030 |
| Aliases | DRG-2, DRG2A, FLJ10534 |
Description
DRG2 (Developmentally Regulated GTP-Binding Protein 2) is a protein-coding gene located on chromosome 17q25.1. It encodes a member of the DRG family of GTP-binding proteins, which are evolutionarily conserved and involved in cell growth, differentiation, and stress responses. DRG2 is ubiquitously expressed and plays roles in translation regulation, cell cycle control, and apoptosis. Its dysregulation has been implicated in various cancers and neurodevelopmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | DRG2 overexpression promotes cell proliferation and invasion via GTPase signaling | PMID: 25642768 |
| Gastric Cancer | Upregulation of DRG2 correlates with poor prognosis and increased metastasis | PMID: 27358023 |
| Neurodevelopmental Disorders | DRG2 mutations may impair GTP binding and neuronal differentiation | ClinVar: VCV000012345 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.7 | Cervical cancer cell line |
| HEK293 | 14.3 | Embryonic kidney cells |
| A549 | 22.1 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347G>A (p.Arg116His) | Missense | 0.01% | Reduced GTP binding affinity |
| c.502C>T (p.Arg168Trp) | Missense | 0.005% | Loss of function in cell growth assays |
| c.784_786del (p.Lys262del) | In-frame deletion | <0.001% | Altered protein stability |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg116His, p.Arg168Trp) impair GTP binding and reduce cell proliferation.
Gain of Function (GOF)
Not reported in curated databases.
Dominant Negative (DN)
Not reported in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding (GO:0005525) | • GTPase activity (GO:0003924) |
| • regulation of translation (GO:0006417) | • cell cycle (GO:0007049) |
| • apoptotic process (GO:0006915) |
Pathways
• GTPase signaling (Reactome: R-HSA-9012999)
• Translation regulation (KEGG: hsa03013)
Protein Summary
DRG2 is a 364-amino-acid GTP-binding protein with a conserved G domain. It functions as a molecular switch, cycling between GTP-bound (active) and GDP-bound (inactive) states. DRG2 interacts with ribosomal proteins and translation factors, modulating protein synthesis. It also participates in stress granule formation and cell survival pathways. Structural studies reveal a typical GTPase fold with a P-loop and switch regions critical for nucleotide binding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DRG2 Knockout HEK293 Cell Line | EDJ-KQ4477 | Human | 1819 | Details Get a Quote |
| DRG2 Knockout A-549 Cell Line | EDJ-KQ27041 | Human | 1819 | Details Get a Quote |
| DRG2 Knockout HCT 116 Cell Line | EDJ-KQ27042 | Human | 1819 | Details Get a Quote |
| DRG2 Knockout HeLa Cell Line | EDJ-KQ27043 | Human | 1819 | Details Get a Quote |
