DRG1: Developmentally Regulated GTP-Binding Protein 1
A comprehensive biomedical resource for DRG1 gene, including genomic annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | DRG1 |
|---|---|
| Full Name | Developmentally Regulated GTP-Binding Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 4733 ncbi.nlm.nih.gov/gene/4733 |
| Ensembl ID | ENSG00000100219 |
| UniProt ID | Q9Y295 |
| OMIM ID | 603952 |
| HGNC ID | 3029 |
| Aliases | NEDD3, DRG-1 |
Description
DRG1 (Developmentally Regulated GTP-Binding Protein 1) is a protein-coding gene that encodes a member of the DRG family of GTP-binding proteins. The protein is involved in cell growth, differentiation, and translation regulation. It is highly conserved across eukaryotes and plays a role in ribosome biogenesis and cellular stress responses. DRG1 is expressed in various tissues and is implicated in several cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of DRG1 promotes cell proliferation and invasion; associated with poor prognosis. | PMID: 25642768 |
| Gastric Cancer | Upregulated in gastric cancer tissues; correlates with tumor stage and metastasis. | PMID: 27381357 |
| Hepatocellular Carcinoma | DRG1 knockdown reduces cell viability and induces apoptosis in liver cancer cells. | PMID: 28407145 |
| Breast Cancer | High DRG1 expression linked to aggressive subtypes and reduced survival. | PMID: 29511318 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.7 | Low |
| Liver | 6.3 | Low |
| Kidney | 5.1 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.5 | Embryonic kidney cells; moderate expression |
| HeLa | 9.8 | Cervical cancer cells; moderate expression |
| MCF7 | 7.2 | Breast cancer cells; low expression |
| HepG2 | 6.1 | Liver cancer cells; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.482G>A (p.Arg161Gln) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.625_627del (p.Lys209del) | In-frame deletion | <0.01% | Unknown; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in DRG1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in DRG1.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in DRG1.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding (GO:0005525) | • GTPase activity (GO:0003924) |
| • ribosome biogenesis (GO:0042254) | • regulation of translation (GO:0006417) |
| • cellular response to stress (GO:0033554) |
Pathways
• Ribosome biogenesis in eukaryotes (KEGG: hsa03008)
• mTOR signaling pathway (Reactome: R-HSA-165159)
Protein Summary
DRG1 is a 367-amino acid GTP-binding protein that belongs to the DRG family. It contains a conserved GTPase domain and is localized to the cytoplasm and nucleus. The protein interacts with ribosomes and translation factors, suggesting a role in protein synthesis regulation. DRG1 is ubiquitously expressed with highest levels in testis. Its expression is developmentally regulated and altered in various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DRG1 Knockout HEK293 Cell Line | EDJ-KQ2184 | Human | 4733 | Details Get a Quote |
| DRG1 Knockout A-549 Cell Line | EDJ-KQ21095 | Human | 4733 | Details Get a Quote |
| DRG1 Knockout HCT 116 Cell Line | EDJ-KQ22405 | Human | 4733 | Details Get a Quote |
| DRG1 Knockout HeLa Cell Line | EDJ-KQ22406 | Human | 4733 | Details Get a Quote |
