DPYSL3
Dihydropyrimidinase Like 3
Gene Information Card
| Symbol | DPYSL3 |
|---|---|
| Full Name | Dihydropyrimidinase Like 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q32 |
| NCBI Gene ID | 1809 ncbi.nlm.nih.gov/gene/1809 |
| Ensembl ID | ENSG00000113648 |
| UniProt ID | Q14195 |
| OMIM ID | 601168 |
| HGNC ID | 3014 |
| Aliases | CRMP4, DRP3, ULIP, CRMP-4, DPYSL3 |
Description
DPYSL3 (dihydropyrimidinase like 3) encodes a member of the collapsin response mediator protein (CRMP) family. The protein is involved in semaphorin signaling, axon guidance, neuronal differentiation, and cytoskeletal dynamics. It is also implicated in cancer cell migration and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression promotes invasion and metastasis via cytoskeletal remodeling | PMID: 23429703 |
| Lung cancer | Upregulation correlates with poor prognosis and increased metastatic potential | PMID: 25642765 |
| Neuroblastoma | Altered expression affects neurite outgrowth and differentiation | PMID: 12477932 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 27.8 | High |
| Cerebral cortex | 32.1 | High |
| Cerebellum | 25.4 | High |
| Testis | 12.3 | Medium |
| Lung | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 35.2 | Neuroblastoma cell line |
| A549 | 18.9 | Lung carcinoma cell line |
| HeLa | 22.5 | Cervical carcinoma cell line |
| HCT116 | 28.1 | Colorectal carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% | Unknown functional impact |
| c.789_791del (p.Phe263del) | In-frame deletion | <0.01% | Alters protein stability |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; rare deletions may impair neurite outgrowth.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function in cell migration.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0007411 (GO:0007411) | • GO:0050808 (GO:0050808) |
| • GO:0030154 (GO:0030154) | • GO:0003779 (GO:0003779) |
| • GO:0005200 (GO:0005200) |
Pathways
• Semaphorin interactions (R-HSA-373755)
• Axon guidance (R-HSA-422475)
• Signaling by Rho GTPases (R-HSA-194315)
Protein Summary
DPYSL3 (CRMP4) is a 62 kDa cytosolic protein that binds tubulin and regulates microtubule dynamics. It mediates semaphorin 3A-induced growth cone collapse and is essential for neuronal polarity. In cancer, DPYSL3 promotes epithelial-mesenchymal transition and metastatic dissemination.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DPYSL3 Knockout HEK293 Cell Line | EDJ-KQ4475 | Human | 1809 | Details Get a Quote |
| DPYSL3 Knockout HCT 116 Cell Line | EDJ-KQ27039 | Human | 1809 | Details Get a Quote |
| DPYSL3 Knockout HeLa Cell Line | EDJ-KQ27040 | Human | 1809 | Details Get a Quote |
| DPYSL3 Knockout A-549 Cell Line | EDJ-KQ25777 | Human | 1809 | Details Get a Quote |
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