DPP9 Gene: Dipeptidyl Peptidase 9
A serine protease involved in immune regulation, cell adhesion, and cancer biology.
Gene Information Card
| Symbol | DPP9 |
|---|---|
| Full Name | Dipeptidyl peptidase 9 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 91039 ncbi.nlm.nih.gov/gene/91039 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | Q86TI2 |
| OMIM ID | 608258 |
| HGNC ID | 20848 |
| Aliases | DP9, DPRP2, DPPRP2 |
Description
DPP9 (Dipeptidyl peptidase 9) is a protein-coding gene that encodes a serine protease belonging to the dipeptidyl peptidase IV (DPPIV) family. The enzyme cleaves N-terminal dipeptides from peptides with proline or alanine in the penultimate position. DPP9 is involved in immune regulation, cell adhesion, and apoptosis. It is ubiquitously expressed with high levels in immune tissues and has been implicated in cancer progression and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression promotes cell proliferation and invasion; modulates immune microenvironment | COSMIC; PubMed studies |
| Inflammatory diseases | Regulates T-cell activation and cytokine processing | UniProt; PubMed |
| Autoimmune disorders | Altered DPP9 activity affects immune tolerance | OMIM; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 24.5 | High |
| Spleen | 22.1 | High |
| Bone marrow | 18.3 | High |
| Lung | 12.7 | Medium |
| Liver | 10.2 | Medium |
| Brain | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney; model for overexpression studies |
| HeLa | 12.8 | Cervical carcinoma; moderate expression |
| K562 | 20.1 | Leukemia; high expression |
| A549 | 14.5 | Lung carcinoma; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1003C>T (p.Arg335Trp) | Missense | Rare | Unknown functional effect; reported in ClinVar |
| c.1427G>A (p.Arg476Gln) | Missense | Rare | Unknown functional effect; reported in ClinVar |
| c.1684C>T (p.Arg562Cys) | Missense | Rare | Unknown functional effect; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in major databases.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in major databases.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Dipeptidyl peptidase IV (DPPIV) family pathway
• Immune system signaling (T-cell activation)
Protein Summary
DPP9 is a 863-amino-acid serine protease that localizes to the cytoplasm and plasma membrane. It functions as a homodimer and cleaves N-terminal dipeptides from substrates such as chemokines and neuropeptides. The protein plays a role in immune regulation by modulating T-cell activity and cytokine processing. DPP9 is overexpressed in several cancers and is considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DPP9 Knockout HEK293 Cell Line | EDJ-KQ10687 | Human | 91039 | Details Get a Quote |
| DPP9 Knockout A-549 Cell Line | EDJ-KQ38227 | Human | 91039 | Details Get a Quote |
| DPP9 Knockout HCT 116 Cell Line | EDJ-KQ38228 | Human | 91039 | Details Get a Quote |
| DPP9 Knockout HeLa Cell Line | EDJ-KQ38229 | Human | 91039 | Details Get a Quote |
