DPP10: Dipeptidyl Peptidase 10 (Inactive)
A non-enzymatic member of the S9B serine protease family involved in neuronal potassium channel modulation and asthma susceptibility.
Gene Information Card
| Symbol | DPP10 |
|---|---|
| Full Name | Dipeptidyl Peptidase 10 (Inactive) |
| Gene Type | Protein coding |
| Chromosomal Location | 2q14.1 |
| NCBI Gene ID | 57628 ncbi.nlm.nih.gov/gene/57628 |
| Ensembl ID | ENSG00000175497 |
| UniProt ID | Q8N608 |
| OMIM ID | 608209 |
| HGNC ID | 20823 |
| Aliases | DPP X, DPRP3, DPL2, DPP10-IT1 |
Description
DPP10 encodes a member of the S9B family of serine proteases, but the encoded protein lacks catalytic activity due to mutations in the active site. It functions as a modulator of voltage-gated potassium channels (Kv4.3) by forming a complex with the channel, thereby regulating neuronal excitability and cardiac repolarization. DPP10 is also implicated in asthma susceptibility through its expression in airway epithelial cells and immune modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | DPP10 variants are associated with altered expression in airway epithelium, influencing inflammatory responses and airway hyperresponsiveness. | GWAS and linkage studies (OMIM 608209) |
| Epilepsy | DPP10 modulates Kv4.3 channels; dysregulation may contribute to neuronal hyperexcitability. | Functional studies (UniProt Q8N608) |
| Bipolar Disorder | Genetic association studies suggest DPP10 polymorphisms may increase risk. | Case-control studies (NCBI Gene) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 8.7 | Low |
| Heart | 6.3 | Low |
| Testis | 4.1 | Not detected |
| Kidney | 3.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 12.5 | Neuronal model |
| A549 (lung carcinoma) | 7.8 | Airway epithelial model |
| HEK293 (embryonic kidney) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Premature truncation, loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.01% | Premature truncation, loss of function |
| c.890A>G (p.Asn297Ser) | Missense | 0.02% | Altered protein stability |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg412*, p.Trp189*) lead to truncated, non-functional protein.
Gain of Function (GOF)
Not reported in DPP10.
Dominant Negative (DN)
Not reported in DPP10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Regulation of cardiac conduction (Kv4.3 channel complex)
• Neuronal system (voltage-gated potassium channels)
Protein Summary
DPP10 is a 796-amino acid type II transmembrane glycoprotein with a large extracellular domain. Despite belonging to the dipeptidyl peptidase family, it lacks catalytic activity due to substitution of the catalytic serine residue. It associates with Kv4.3 potassium channels to modulate their gating properties, influencing action potential duration and neuronal firing. The protein is predominantly expressed in brain and lung tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DPP10 Knockout HEK293 Cell Line | EDJ-KQ13205 | Human | 57628 | Details Get a Quote |
| DPP10 Knockout HeLa Cell Line | EDJ-KQ56887 | Human | 57628 | Details Get a Quote |
| DPP10 Knockout A-549 Cell Line | EDJ-KQ65400 | Human | 57628 | Details Get a Quote |
| DPP10 Knockout HCT 116 Cell Line | EDJ-KQ73837 | Human | 57628 | Details Get a Quote |
