DOP1A
DOP1 Leucine Zipper Like Protein A
Gene Information Card
| Symbol | DOP1A |
|---|---|
| Full Name | DOP1 Leucine Zipper Like Protein A |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.4 |
| NCBI Gene ID | 729430 ncbi.nlm.nih.gov/gene/729430 |
| Ensembl ID | ENSG00000197826 |
| UniProt ID | Q8N5M9 |
| OMIM ID | 618425 |
| HGNC ID | 28235 |
| Aliases | DOP1, FLJ10769, KIAA1817 |
Description
DOP1A encodes a protein that contains a leucine zipper domain and is involved in vesicle-mediated protein trafficking, particularly at the Golgi apparatus. It is part of the DOP1 family and plays a role in maintaining Golgi structure and function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.0 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • Golgi apparatus | • protein transport |
| • vesicle-mediated transport | • leucine zipper domain |
Pathways
• Vesicle-mediated transport
• Golgi-to-ER retrograde transport
Protein Summary
DOP1A is a 1,081-amino acid protein with a leucine zipper motif, localized to the Golgi apparatus. It is implicated in tethering and fusion of transport vesicles, contributing to Golgi integrity and protein sorting.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DOP1A Knockout HEK293 Cell Line | EDJ-KQ3314 | Human | 23033 | Details Get a Quote |
| DOP1A Knockout HeLa Cell Line | EDJ-KQ24917 | Human | 23033 | Details Get a Quote |
| DOP1A Knockout HCT 116 Cell Line | EDJ-KQ23530 | Human | 23033 | Details Get a Quote |
| DOP1A Knockout A-549 Cell Line | EDJ-KQ24915 | Human | 23033 | Details Get a Quote |
