DNAJC25-GNG10
Readthrough transcript between DNAJC25 and GNG10 genes
Gene Information Card
| Symbol | DNAJC25-GNG10 |
|---|---|
| Full Name | DNAJC25-GNG10 readthrough |
| Gene Type | Readthrough transcript (protein-coding) |
| Chromosomal Location | 9q21.32 |
| NCBI Gene ID | 100528031 ncbi.nlm.nih.gov/gene/100528031 |
| Ensembl ID | ENSG00000269317 |
| UniProt ID | Not available (readthrough transcript) |
| OMIM ID | Not available |
| HGNC ID | HGNC:40153 |
| Aliases | DNAJC25-GNG10 readthrough, DNAJC25//GNG10 |
Description
DNAJC25-GNG10 is a readthrough transcript that spans the DNAJC25 and GNG10 genes on chromosome 9q21.32. This naturally occurring readthrough product produces a fusion protein that shares sequence identity with both the DnaJ (Hsp40) homolog, subfamily C, member 25 (DNAJC25) and the guanine nucleotide-binding protein subunit gamma-10 (GNG10). The biological significance of this readthrough transcript is not fully characterized, but it may contribute to cellular chaperone and G-protein signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available | N/A | No nTPM values reported for this readthrough transcript |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The DNAJC25-GNG10 readthrough transcript is predicted to produce a fusion protein combining the N-terminal DnaJ domain from DNAJC25 and the C-terminal G-protein gamma subunit domain from GNG10. No experimental protein evidence is currently available in UniProt for this readthrough product.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DNAJC25-GNG10 Knockout HEK293 Cell Line | EDJ-KQ52368 | Human | 552891 | Details Get a Quote |
| DNAJC25-GNG10 Knockout HeLa Cell Line | EDJ-KQ60503 | Human | 552891 | Details Get a Quote |
| DNAJC25-GNG10 Knockout A-549 Cell Line | EDJ-KQ68973 | Human | 552891 | Details Get a Quote |
| DNAJC25-GNG10 Knockout HCT 116 Cell Line | EDJ-KQ77331 | Human | 552891 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
