DNAJB14
DnaJ Heat Shock Protein Family (Hsp40) Member B14
Gene Information Card
| Symbol | DNAJB14 |
|---|---|
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member B14 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q22.1 |
| NCBI Gene ID | 79982 ncbi.nlm.nih.gov/gene/79982 |
| Ensembl ID | ENSG00000164111 |
| UniProt ID | Q8TBM8 |
| OMIM ID | 617042 |
| HGNC ID | 29231 |
| Aliases | FLJ10305, DKFZp686B10110 |
Description
DNAJB14 encodes a member of the DnaJ/Hsp40 family of co-chaperones, which stimulate the ATPase activity of Hsp70 chaperones and assist in protein folding, trafficking, and degradation. The protein contains a conserved J-domain and is implicated in cellular stress responses and protein quality control.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect Hsp70 chaperone activity, influencing tumor growth and apoptosis | COSMIC; literature |
| Neurodegenerative disorders | Dysregulation of protein folding and aggregation pathways | Inferred from family function; limited direct evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.5 | Low |
| Heart | 6.2 | Low |
| Liver | 4.1 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown; predicted benign |
| c.205G>A (p.Gly69Ser) | Missense | <0.01% | Unknown; predicted tolerated |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein folding (GO:0006457) | • Hsp70 protein binding (GO:0030544) |
| • ATP binding (GO:0005524) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) |
Pathways
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
• Hsp70 chaperone cycle (Reactome: R-HSA-3371568)
Protein Summary
DNAJB14 is a 338-amino-acid co-chaperone with a conserved J-domain that interacts with Hsp70 to facilitate protein folding and quality control. It is widely expressed at low to moderate levels, with highest abundance in testis. Its role in disease is not well characterized, but it may contribute to cancer and neurodegenerative processes through chaperone network dysregulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DNAJB14 Knockout HEK293 Cell Line | EDJ-KQ13185 | Human | 79982 | Details Get a Quote |
| DNAJB14 Knockout HCT 116 Cell Line | EDJ-KQ41314 | Human | 79982 | Details Get a Quote |
| DNAJB14 Knockout A-549 Cell Line | EDJ-KQ42544 | Human | 79982 | Details Get a Quote |
| DNAJB14 Knockout HeLa Cell Line | EDJ-KQ42546 | Human | 79982 | Details Get a Quote |
