DNAJA4: DnaJ Heat Shock Protein Family (Hsp40) Member A4
A co-chaperone regulating protein folding, stress response, and potential implications in cancer and neurodegenerative disorders.
Gene Information Card
| Symbol | DNAJA4 |
|---|---|
| Full Name | DnaJ heat shock protein family (Hsp40) member A4 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q25.1 |
| NCBI Gene ID | 55466 ncbi.nlm.nih.gov/gene/55466 |
| Ensembl ID | ENSG00000140403 |
| UniProt ID | Q8WW22 |
| OMIM ID | 611323 |
| HGNC ID | 14885 |
| Aliases | HDJ2, HSPF4, DNAJA4, Dj4 |
Description
DNAJA4 encodes a member of the DnaJ/Hsp40 family of co-chaperones. The protein contains a conserved J-domain that interacts with Hsp70 chaperones to facilitate protein folding, translocation, and degradation. DNAJA4 is involved in cellular stress responses, including heat shock and oxidative stress, and may play roles in tumorigenesis and neurodegeneration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect Hsp70-mediated protein homeostasis, promoting cell survival under stress. | COSMIC; literature |
| Neurodegenerative disorders | Co-chaperone dysfunction can lead to protein aggregation (e.g., in Alzheimer's, Parkinson's). | UniProt; literature |
| Heat shock response | Induced under thermal stress to protect cells from proteotoxicity. | NCBI Gene; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 10.2 | Moderate expression |
| K562 | 7.5 | Low expression |
| A549 | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown; predicted damaging |
| c.1012G>A (p.Gly338Ser) | Missense | <0.01% | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein folding (GO:0006457) | • response to heat (GO:0009408) |
| • Hsp70 protein binding (GO:0030544) | • ATP binding (GO:0005524) |
| • cytoplasm (GO:0005737) |
Pathways
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
• Antigen processing and cross-presentation (Reactome: R-HSA-1236974)
Protein Summary
DNAJA4 is a 397-amino acid protein (UniProt Q8WW22) with a J-domain at the N-terminus (residues 1-70) that mediates interaction with Hsp70. It functions as a co-chaperone to stimulate ATPase activity of Hsp70, assisting in protein folding and quality control. The protein is localized in the cytoplasm and is induced under stress conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DNAJA4 Knockout HEK293 Cell Line | EDJ-KQ13179 | Human | 55466 | Details Get a Quote |
| DNAJA4 Knockout HCT 116 Cell Line | EDJ-KQ42536 | Human | 55466 | Details Get a Quote |
| DNAJA4 Knockout HeLa Cell Line | EDJ-KQ42537 | Human | 55466 | Details Get a Quote |
| DNAJA4 Knockout A-549 Cell Line | EDJ-KQ65085 | Human | 55466 | Details Get a Quote |
