DKK2 Gene - Dickkopf WNT Signaling Pathway Inhibitor 2
Comprehensive gene card for DKK2, a key regulator of the WNT signaling pathway involved in development and disease.
Gene Information Card
| Symbol | DKK2 |
|---|---|
| Full Name | Dickkopf WNT Signaling Pathway Inhibitor 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q25 |
| NCBI Gene ID | 27123 ncbi.nlm.nih.gov/gene/27123 |
| Ensembl ID | ENSG00000155090 |
| UniProt ID | Q9UBU2 |
| OMIM ID | 605415 |
| HGNC ID | 2892 |
| Aliases | Dickkopf-2, DKK-2 |
Description
DKK2 (Dickkopf WNT Signaling Pathway Inhibitor 2) is a protein-coding gene that encodes a secreted protein belonging to the Dickkopf family. The protein functions as an antagonist of the canonical WNT/β-catenin signaling pathway by binding to LRP5/6 co-receptors. DKK2 plays critical roles in embryonic development, bone formation, and cell proliferation. Dysregulation of DKK2 is implicated in various cancers, including colorectal, gastric, and breast cancer, as well as in bone disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | DKK2 overexpression inhibits WNT signaling, promoting tumor progression via alternative pathways | PMID: 25642764 |
| Gastric Cancer | Epigenetic silencing of DKK2 leads to aberrant WNT activation | PMID: 21750109 |
| Osteoporosis | DKK2 regulates osteoblast differentiation; altered expression affects bone density | PMID: 19056867 |
| Breast Cancer | DKK2 methylation status correlates with metastasis and poor prognosis | PMID: 23542377 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Adipose tissue | 6.1 | Low |
| Heart | 4.3 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Embryonic kidney cells; moderate expression |
| HeLa | 9.8 | Cervical cancer cells; low expression |
| MCF7 | 7.5 | Breast cancer cells; low expression |
| HCT116 | 5.2 | Colorectal cancer cells; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1?; start codon loss, likely loss of function |
| c.214C>T | Nonsense | <0.01% | p.Gln72*; premature stop, loss of function |
| c.458G>A | Missense | <0.01% | p.Arg153His; unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein or nonsense-mediated decay.
Gain of Function (GOF)
Not reported in literature.
Dominant Negative (DN)
Not reported in literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Regulation of beta-catenin signaling (Reactome: R-HSA-4641262)
Protein Summary
The DKK2 protein is a 259-amino acid secreted glycoprotein containing two cysteine-rich domains. It binds to LRP5/6 and Kremen receptors, forming a ternary complex that promotes LRP5/6 internalization, thereby inhibiting canonical WNT signaling. DKK2 is involved in head induction, limb development, and bone homeostasis. Its expression is tightly regulated; aberrant methylation or mutation contributes to oncogenesis and skeletal disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DKK2 Knockout HEK293 Cell Line | EDJ-KQ295 | Human | 27123 | Details Get a Quote |
| DKK2 Knockout HeLa Cell Line | EDJ-KQ56006 | Human | 27123 | Details Get a Quote |
| DKK2 Knockout A-549 Cell Line | EDJ-KQ64494 | Human | 27123 | Details Get a Quote |
| DKK2 Knockout HCT 116 Cell Line | EDJ-KQ72952 | Human | 27123 | Details Get a Quote |
