DHRS13: Dehydrogenase/Reductase 13
A short-chain dehydrogenase/reductase with potential roles in cellular metabolism and disease.
Gene Information Card
| Symbol | DHRS13 |
|---|---|
| Full Name | Dehydrogenase/Reductase 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 147015 ncbi.nlm.nih.gov/gene/147015 |
| Ensembl ID | ENSG00000187608 |
| UniProt ID | Q6UWP2 |
| OMIM ID | 617203 |
| HGNC ID | 28431 |
| Aliases | SDR36C1, FLJ20489 |
Description
DHRS13 (Dehydrogenase/Reductase 13) encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The protein is predicted to function as an oxidoreductase, potentially involved in the metabolism of steroids, retinoids, and other lipids. It is widely expressed in human tissues and has been implicated in cellular stress responses and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may influence tumor metabolism and proliferation; DHRS13 is upregulated in some breast cancer subtypes. | NCBI Gene, COSMIC |
| Colorectal cancer | Mutations and copy number alterations observed; potential role in metabolic reprogramming. | COSMIC, ClinVar |
| Prostate cancer | Overexpression reported; may affect androgen metabolism. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 8.7 | Medium |
| Brain | 6.3 | Low |
| Lung | 9.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.3 | Hepatocellular carcinoma cell line |
| MCF7 | 11.8 | Breast cancer cell line |
| A549 | 9.5 | Lung carcinoma cell line |
| HEK293 | 7.2 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.314A>G (p.Tyr105Cys) | Missense | <0.01% | Unknown functional impact; rare in population databases |
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Predicted possibly damaging by in silico tools |
| c.602C>T (p.Pro201Leu) | Missense | <0.01% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in literature.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • oxidoreductase activity (GO:0016491) | • oxidation-reduction process (GO:0055114) |
| • cytoplasm (GO:0005737) | • cytosol (GO:0005829) |
Pathways
• Metabolic pathways (Reactome)
• Phase I functionalization of compounds (Reactome)
Protein Summary
DHRS13 is a 317-amino acid protein belonging to the short-chain dehydrogenase/reductase (SDR) family. It contains a conserved NAD(P)-binding Rossmann fold domain and is predicted to catalyze the reduction of carbonyl groups. The protein is localized in the cytoplasm and cytosol, and its expression is highest in liver and kidney. Structural studies suggest it may act on steroid or retinoid substrates, though specific physiological substrates remain to be confirmed.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DHRS13 Knockout HEK293 Cell Line | EDJ-KQ2943 | Human | 147015 | Details Get a Quote |
| DHRS13 Knockout A-549 Cell Line | EDJ-KQ24066 | Human | 147015 | Details Get a Quote |
| DHRS13 Knockout HCT 116 Cell Line | EDJ-KQ24067 | Human | 147015 | Details Get a Quote |
| DHRS13 Knockout HeLa Cell Line | EDJ-KQ24068 | Human | 147015 | Details Get a Quote |
