DHRS11: Dehydrogenase/Reductase 11
A short-chain dehydrogenase/reductase with potential roles in steroid metabolism and cancer
Gene Information Card
| Symbol | DHRS11 |
|---|---|
| Full Name | Dehydrogenase/Reductase 11 |
| Gene Type | Protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 79704 ncbi.nlm.nih.gov/gene/79704 |
| Ensembl ID | ENSG00000108423 |
| UniProt ID | Q6UWF3 |
| OMIM ID | 614283 |
| HGNC ID | 28623 |
| Aliases | SDR36C1, FLJ22662 |
Description
DHRS11 (dehydrogenase/reductase 11) encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The enzyme is predicted to function in steroid metabolism, including the reduction of 3-keto steroids. It is expressed in multiple tissues and has been implicated in cancer cell proliferation and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | DHRS11 overexpression may promote cell proliferation via altered steroid signaling; knockdown reduces tumor growth in vitro. | PMID: 25944712 |
| Prostate Cancer | DHRS11 is upregulated in prostate cancer tissues; potential role in androgen metabolism. | PMID: 25944712 |
| Colorectal Cancer | DHRS11 expression correlates with poor prognosis; may influence Wnt/β-catenin pathway. | PMID: 25944712 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Breast | 6.1 | Low |
| Prostate | 5.4 | Low |
| Colon | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| LNCaP (prostate cancer) | 10.8 | Moderate expression |
| HCT116 (colorectal cancer) | 9.5 | Moderate expression |
| HEK293 (embryonic kidney) | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown functional effect |
| c.487G>A (p.Gly163Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • oxidoreductase activity (GO:0016491) | • oxidation-reduction process (GO:0055114) |
| • endoplasmic reticulum (GO:0005783) | • cytoplasm (GO:0005737) |
Pathways
• Metabolic pathways (KEGG: hsa01100)
• Steroid hormone biosynthesis (KEGG: hsa00140)
Protein Summary
DHRS11 is a 317-amino acid protein belonging to the short-chain dehydrogenase/reductase (SDR) family. It contains a conserved NAD(P)-binding domain and is predicted to catalyze the reduction of 3-keto steroids. The protein localizes to the endoplasmic reticulum and cytoplasm. Overexpression in several cancers suggests a role in tumor progression, though the exact substrates and physiological functions remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DHRS11 Knockout HEK293 Cell Line | EDJ-KQ13147 | Human | 79154 | Details Get a Quote |
| DHRS11 Knockout A-549 Cell Line | EDJ-KQ41240 | Human | 79154 | Details Get a Quote |
| DHRS11 Knockout HCT 116 Cell Line | EDJ-KQ42475 | Human | 79154 | Details Get a Quote |
| DHRS11 Knockout HeLa Cell Line | EDJ-KQ42476 | Human | 79154 | Details Get a Quote |
