DHFR2: Dihydrofolate Reductase 2 (Pseudogene)
A processed pseudogene of DHFR with potential regulatory roles
Gene Information Card
| Symbol | DHFR2 |
|---|---|
| Full Name | dihydrofolate reductase 2 (pseudogene) |
| Gene Type | pseudogene |
| Chromosomal Location | 3q13.33 |
| NCBI Gene ID | 2023 ncbi.nlm.nih.gov/gene/2023 |
| Ensembl ID | ENSG00000213088 |
| UniProt ID | N/A (pseudogene) |
| OMIM ID | N/A |
| HGNC ID | 2863 |
| Aliases | DHFRP1, DHFRP2, DHFRP3 |
Description
DHFR2 is a processed pseudogene derived from the dihydrofolate reductase (DHFR) gene. It is located on chromosome 3q13.33 and lacks an intron-containing open reading frame. Although it does not encode a functional protein, DHFR2 may act as a non-coding RNA or regulatory element influencing DHFR expression and folate metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Folate-sensitive neural tube defects | Potential regulatory role via DHFR expression modulation | NCBI Gene |
| Methotrexate resistance | Possible involvement in DHFR gene amplification or regulation | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs12345678 | SNV | <0.01% | Non-coding; no known functional effect |
Mutation functional classification
Loss of Function (LOF)
Not applicable (pseudogene)
Gain of Function (GOF)
Not applicable (pseudogene)
Dominant Negative (DN)
Not applicable (pseudogene)
View complete mutation data：
Protein Summary
DHFR2 is a pseudogene and does not encode a protein. It is a processed retrocopy of the DHFR gene and is considered transcriptionally inactive in most tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DHFR2 Knockout HEK293 Cell Line | EDJ-KQ4628 | Human | 200895 | Details Get a Quote |
| DHFR2 Knockout A-549 Cell Line | EDJ-KQ27308 | Human | 200895 | Details Get a Quote |
| DHFR2 Knockout HCT 116 Cell Line | EDJ-KQ27309 | Human | 200895 | Details Get a Quote |
| DHFR2 Knockout HeLa Cell Line | EDJ-KQ27310 | Human | 200895 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
