DGKG (Diacylglycerol Kinase Gamma)
A key regulator of diacylglycerol signaling in cellular processes, with implications in cancer and neurological disorders.
Gene Information Card
| Symbol | DGKG |
|---|---|
| Full Name | Diacylglycerol Kinase Gamma |
| Gene Type | Protein coding |
| Chromosomal Location | 3q27.2 |
| NCBI Gene ID | 1608 ncbi.nlm.nih.gov/gene/1608 |
| Ensembl ID | ENSG00000100077 |
| UniProt ID | P49619 |
| OMIM ID | 601854 |
| HGNC ID | 2854 |
| Aliases | DGK-gamma, DAGK3, DAGK-gamma |
Description
DGKG encodes diacylglycerol kinase gamma, an enzyme that phosphorylates diacylglycerol (DAG) to phosphatidic acid (PA), thereby regulating DAG-mediated signaling pathways. This protein is involved in cell proliferation, differentiation, and apoptosis. DGKG is expressed in multiple tissues, with highest levels in the brain and retina. Alterations in DGKG have been linked to cancer and neurological conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered DGKG expression may disrupt DAG signaling, affecting cell growth and survival pathways. | COSMIC; literature |
| Retinal degeneration | DGKG is highly expressed in retina; dysfunction may impair phototransduction or cell survival. | UniProt; literature |
| Neurological disorders | DGKG modulates synaptic signaling; variants may contribute to epilepsy or cognitive deficits. | ClinVar; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Retina | 15.0 | High |
| Heart | 4.2 | Medium |
| Lung | 2.1 | Low |
| Liver | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.5 | High expression |
| SH-SY5Y | 10.2 | Neuronal cell line |
| HeLa | 3.0 | Moderate expression |
| MCF7 | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01% | Unknown functional effect |
| c.567_568insA | Frameshift | <0.01% | Likely loss of function |
| c.890G>A (p.Arg297Gln) | Missense | <0.01% | Reported in ClinVar as uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to truncated protein and loss of kinase activity.
Gain of Function (GOF)
Not well characterized; some missense variants may alter substrate specificity.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • diacylglycerol kinase activity | • ATP binding |
| • calcium ion binding | • zinc ion binding |
| • phosphatidic acid biosynthetic process | • signal transduction |
| • cell proliferation | • nervous system development |
Pathways
• Diacylglycerol kinase pathway
• Phospholipid metabolism
• GPCR signaling
• VEGF signaling
Protein Summary
Diacylglycerol kinase gamma (DGK-gamma) is a 791-amino acid protein that converts DAG to PA, terminating DAG signaling and generating PA as a second messenger. It contains a catalytic domain, two EF-hand motifs for calcium binding, and a C1 domain for DAG binding. DGK-gamma is predominantly cytosolic but translocates to membranes upon activation. It plays roles in cell cycle control, neuronal function, and immune responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DGKG Knockout HEK293 Cell Line | EDJ-KQ1697 | Human | 1608 | Details Get a Quote |
| DGKG Knockout A-549 Cell Line | EDJ-KQ21511 | Human | 1608 | Details Get a Quote |
| DGKG Knockout HCT 116 Cell Line | EDJ-KQ21512 | Human | 1608 | Details Get a Quote |
| DGKG Knockout HeLa Cell Line | EDJ-KQ53067 | Human | 1608 | Details Get a Quote |
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