DEPP1: Decidual Protein Induced by Progesterone
Autophagy regulator and stress-response gene implicated in cancer and metabolic disorders
Gene Information Card
| Symbol | DEPP1 |
|---|---|
| Full Name | Decidual Protein Induced by Progesterone 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q11.22 |
| NCBI Gene ID | 81929 ncbi.nlm.nih.gov/gene/81929 |
| Ensembl ID | ENSG00000165806 |
| UniProt ID | Q9NTK1 |
| OMIM ID | 611689 |
| HGNC ID | 28370 |
| Aliases | FAM47B, DEPP |
Description
DEPP1 (Decidual Protein Induced by Progesterone 1) is a protein-coding gene located on chromosome 10q11.22. It encodes a protein involved in autophagy regulation, particularly in response to hormonal and stress signals. DEPP1 is induced by progesterone and plays a role in decidualization, cell survival, and metabolic adaptation. It has been implicated in various cancers and metabolic disorders through its modulation of autophagic flux and mitochondrial function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | DEPP1 overexpression promotes autophagy and chemoresistance in breast cancer cells. | PMID: 25605274 |
| Colorectal cancer | DEPP1 is upregulated and associated with poor prognosis; modulates autophagy and cell proliferation. | PMID: 29057922 |
| Endometrial cancer | DEPP1 expression is induced by progesterone and linked to decidualization defects. | PMID: 21900404 |
| Obesity and insulin resistance | DEPP1 regulates autophagy in adipose tissue, influencing metabolic homeostasis. | PMID: 27184846 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 6.1 | Low |
| Endometrium | 15.2 | Medium |
| Liver | 4.7 | Low |
| Placenta | 18.9 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | 14.2 | Progesterone-induced expression |
| HCT116 (colorectal cancer) | 9.8 | Basal expression |
| HepG2 (liver cancer) | 5.3 | Low expression |
| T47D (breast cancer) | 16.5 | High expression upon progesterone treatment |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.124C>T | Synonymous | 0.02% | No known effect |
| c.256G>A | Missense | <0.01% | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in DEPP1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in DEPP1.
Dominant Negative (DN)
No dominant-negative mutations reported in DEPP1.
View complete mutation data：
Gene Ontology (GO)
| • autophagy (GO:0006914) | • negative regulation of apoptotic process (GO:0043066) |
| • mitochondrion (GO:0005739) | • nucleus (GO:0005634) |
| • identical protein binding (GO:0042802) |
Pathways
• Autophagy - organism-specific biosystem
• Progesterone-mediated oocyte maturation
• FoxO signaling pathway
Protein Summary
The DEPP1 protein (UniProt Q9NTK1) is a 244-amino acid protein localized to the nucleus and mitochondria. It functions as a positive regulator of autophagy, promoting autophagosome formation and autophagic flux under stress conditions. DEPP1 is induced by progesterone and other hormonal signals, and its expression modulates cell survival, metabolism, and differentiation. The protein interacts with key autophagy regulators and influences mitochondrial dynamics.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DEPP1 Knockout HeLa Cell Line | EDJ-KQ31 | Human | 11067 | Details Get a Quote |
| DEPP1 Knockout HEK293 Cell Line | EDJ-KQ7266 | Human | 11067 | Details Get a Quote |
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