DEPDC1B
DEP Domain Containing 1B – A Regulator of Cell Cycle and Migration
Gene Information Card
| Symbol | DEPDC1B |
|---|---|
| Full Name | DEP domain containing 1B |
| Gene Type | Protein coding |
| Chromosomal Location | 5q12.1 |
| NCBI Gene ID | 55789 ncbi.nlm.nih.gov/gene/55789 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q8N6Q3 |
| OMIM ID | 612564 |
| HGNC ID | 28423 |
| Aliases | BRCC3, DEP.1B, XTP1 |
Description
DEPDC1B (DEP domain containing 1B) encodes a protein that contains a DEP domain, which is involved in regulating G-protein signaling. The protein plays a role in cell cycle progression, cytokinesis, and cell migration. DEPDC1B is implicated in several cancers, where it may promote tumor growth and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and migration via Rho GTPase signaling | PMID: 25605248 |
| Lung cancer | Upregulation correlates with poor prognosis and enhanced invasion | PMID: 28925394 |
| Hepatocellular carcinoma | DEPDC1B knockdown reduces cell growth and metastasis | PMID: 30523342 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 6.1 | Low |
| Brain | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Moderate expression |
| A549 | 10.1 | Low expression |
| MCF7 | 18.7 | Moderate expression |
| HEK 293 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | 0.02% (gnomAD) | Unknown functional impact |
| c.1456G>A (p.Glu486Lys) | Missense | 0.01% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • cell cycle |
| • cytokinesis | • cell migration |
| • Rho protein signal transduction |
Pathways
• Rho GTPase cycle
• Signaling by Rho GTPases
Protein Summary
The DEPDC1B protein (UniProt Q8N6Q3) contains a DEP domain and is localized to the cytoplasm and midbody during cytokinesis. It interacts with Rho family GTPases to regulate actin cytoskeleton dynamics, cell division, and motility. Overexpression in various cancers suggests an oncogenic role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DEPDC1B Knockout HEK293 Cell Line | EDJ-KQ2449 | Human | 55789 | Details Get a Quote |
| DEPDC1B Knockout HCT 116 Cell Line | EDJ-KQ22975 | Human | 55789 | Details Get a Quote |
| DEPDC1B Knockout HeLa Cell Line | EDJ-KQ22976 | Human | 55789 | Details Get a Quote |
| DEPDC1B Knockout A-549 Cell Line | EDJ-KQ21645 | Human | 55789 | Details Get a Quote |
