DENR Gene (Density-Regulated Protein)
A gene encoding a translation initiation factor involved in cellular stress response and cancer
Gene Information Card
| Symbol | DENR |
|---|---|
| Full Name | Density-Regulated Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 8562 ncbi.nlm.nih.gov/gene/8562 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | O43583 |
| OMIM ID | 604550 |
| HGNC ID | 2852 |
| Aliases | DRP, DRP1, SMAP-1 |
Description
The DENR gene encodes the density-regulated protein, a component of the translation initiation complex that promotes reinitiation of translation on short upstream open reading frames (uORFs). It is involved in cellular stress responses, cell proliferation, and has been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Overexpression promotes translation of oncogenic mRNAs | PMID: 25609616 |
| Breast cancer | Upregulation correlates with poor prognosis | PMID: 29367642 |
| Lung cancer | DENR knockdown reduces cell proliferation | PMID: 31073084 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Brain | 8.1 | Low |
| Liver | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.0 | Cervical cancer cell line |
| A549 | 12.8 | Lung cancer cell line |
| MCF7 | 11.5 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations predicted to cause premature truncation and loss of function.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity (GO:0003743) | • regulation of translation (GO:0006417) |
| • cytoplasmic translational initiation (GO:0002183) |
Pathways
• REACT:16888 - Translation initiation
• KEGG:03013 - RNA transport
Protein Summary
The DENR protein (O43583) is a 226-amino acid translation initiation factor that forms a complex with MCTS1. It facilitates ribosome recycling and reinitiation after uORF translation, playing a key role in stress-responsive gene expression. Overexpression in cancer cells promotes proliferation and resistance to apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DENR Knockout HEK293 Cell Line | EDJ-KQ50797 | Human | 8562 | Details Get a Quote |
| DENR Knockout HeLa Cell Line | EDJ-KQ54941 | Human | 8562 | Details Get a Quote |
| DENR Knockout A-549 Cell Line | EDJ-KQ63426 | Human | 8562 | Details Get a Quote |
| DENR Knockout HCT 116 Cell Line | EDJ-KQ71892 | Human | 8562 | Details Get a Quote |
